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Article
Open AccessC-C motif chemokine receptor 2 and 7 synergistically control inflammatory monocyte recruitment but the infecting virus dictates monocyte function in the brain
Inflammatory monocytes (iMO) are recruited from the bone marrow to the brain during viral encephalitis. C-C motif chemokine receptor (CCR) 2 deficiency substantially reduces iMO recruitment for most, but not a...
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Article
Depleting myeloid-biased haematopoietic stem cells rejuvenates aged immunity
Ageing of the immune system is characterized by decreased lymphopoiesis and adaptive immunity, and increased inflammation and myeloid pathologies1,2. Age-related changes in populations of self-renewing haematopoi...
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Article
Open AccessNeuronal maturation reduces the type I IFN response to orthobunyavirus infection and leads to increased apoptosis of human neurons
La Crosse virus (LACV) is the leading cause of pediatric arboviral encephalitis in the USA. LACV encephalitis can result in learning and memory deficits, which may be due to infection and apoptosis of neurons ...
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Article
Open AccessA functional subset of CD8+ T cells during chronic exhaustion is defined by SIRPα expression
Prolonged exposure of CD8+ T cells to antigenic stimulation, as in chronic viral infections, leads to a state of diminished function termed exhaustion. We now demonstrate that even during exhaustion there is a su...
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Article
Open AccessLymphocytes have a role in protection, but not in pathogenesis, during La Crosse Virus infection in mice
La Crosse Virus (LACV) is a primary cause of pediatric viral encephalitis in the USA and can result in severe clinical outcomes. Almost all cases of LACV encephalitis occur in children 16 years or younger, ind...
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Article
Open AccessAge-related differences in neuroinflammatory responses associated with a distinct profile of regulatory markers on neonatal microglia
The perinatal period is one in which the mammalian brain is particularly vulnerable to immune-mediated damage. Early inflammation in the central nervous system (CNS) is linked with long-term impairment in lear...
