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  1. No Access

    Article

    Crosstalk between small-cell lung cancer cells and astrocytes mimics brain development to promote brain metastasis

    Brain metastases represent an important clinical problem for patients with small-cell lung cancer (SCLC). However, the mechanisms underlying SCLC growth in the brain remain poorly understood. Here, using intra...

    Fangfei Qu, Siqi C. Brough, Wojciech Michno, Chioma J. Madubata… in Nature Cell Biology (2023)

  2. Article

    Open Access

    Radiotherapy in combination with CD47 blockade elicits a macrophage-mediated abscopal effect

    Radiation therapy is a mainstay of cancer treatment but does not always lead to complete tumor regression. Here we combine radiotherapy with blockade of the ‘don’t-eat-me’ cell-surface molecule CD47 in small c...

    Yoko Nishiga, Alexandros P. Drainas, Maya Baron, Debadrita Bhattacharya… in Nature Cancer (2022)

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  3. No Access

    Article

    ATR kinase regulates its attenuation via PPM1D phosphatase recruitment to chromatin during recovery from DNA replication stress signalling

    In eukaryotes, in response to replication stress, DNA damage response kinase, ATR is activated, whose signalling abrogation leads to cell lethality due to aberrant fork remodelling and excessive origin firing....

    Debadrita Bhattacharya, Disha Hiregange, Basuthkar J Rao in Journal of Biosciences (2018)

  4. No Access

    Article

    Data-Modeling Identifies Conflicting Signaling Axes Governing Myoblast Proliferation and Differentiation Responses to Diverse Ligand Stimuli

    Skeletal muscle tissue development and regeneration relies on the proliferation, maturation and fusion of muscle progenitor cells (myoblasts), which arise transiently from muscle stem cells (satellite cells). ...

    Alexander M. Loiben, Sharon Soueid-Baumgarten… in Cellular and Molecular Bioengineering (2017)