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  1. Article

    Open Access

    Smoking in preeclamptic women is associated with higher birthweight for gestational age and lower soluble fms-like tyrosine kinase-1 levels: a nested case control study

    Smoking paradoxically increases the risk of small-for-gestational-age (SGA) birth but protects against preeclampsia. Some studies have reported a "U-shaped" distribution of fetal growth in preeclamptic pregnan...

    Susan R Kahn, Nisha D Almeida, Helen McNamara, Gideon Koren… in BMC Pregnancy and Childbirth (2011)

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  2. Article

    Open Access

    Sphingomyelin phosphodiesterase-1 (SMPD1) coding variants do not contribute to low levels of high-density lipoprotein cholesterol

    Niemann-Pick disease type A and B is caused by a deficiency of acid sphingomyelinase due to mutations in the sphingomyelin phosphodiesterase-1 (SMPD1) gene. In Niemann-Pick patients, SMPD1 gene defects are report...

    Zari Dastani, Isabelle L Ruel, James C Engert, Jacques Genest Jr… in BMC Medical Genetics (2007)

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  3. No Access

    Article

    Compound heterozygosity at the sphingomyelin phosphodiesterase-1 (SMPD1) gene is associated with low HDL cholesterol

    Type A and B forms of Niemann-Pick disease (NPD) are lipid storage disorders caused by deficient activity of the enzyme acid sphingomyelinase (aSMase) and the resulting accumulation of sphingomyelin in tissues...

    Ching Yin Lee, Larbi Krimbou, Jérôme Vincent, Chantal Bernard… in Human Genetics (2003)

  4. No Access

    Article

    Plasma homocysteine concentration in children with chronic renal failure

    Hyperhomocysteinemia, a risk factor for vascular disease, is commonly found in adult patients with end-stage renal disease. Major determinants of elevated plasma homocysteine levels in these patients include ...

    A. Merouani, Marie Lambert, Edgar E. Delvin, Jacques Genest Jr.… in Pediatric Nephrology (2001)

  5. No Access

    Chapter

    Homocysteine and Family History of Coronary Artery Disease

    The risk of develo** coronary artery disease (CAD) or atherosclerosis in other vascular beds can be estimated by determining the presence of conventional risk factors (age, gender, family history, plasma lip...

    Jacques Genest Jr. in Homocysteine and Vascular Disease (2000)

  6. No Access

    Article

    Mutations in ABC1 in Tangier disease and familial high-density lipoprotein deficiency

    Genes have a major role in the control of high-density lipoprotein (HDL) cholesterol (HDL-C) levels. Here we have identified two Tangier disease (TD) families, confirmed 9q31 linkage and refined the disease lo...

    Angela Brooks-Wilson, Michel Marcil, Susanne M. Clee, Lin-Hua Zhang… in Nature Genetics (1999)