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Article
Open AccessMetabolic effects of leptin receptor knockdown or reconstitution in adipose tissues
The relative contribution of peripheral and central leptin signalling to the regulation of metabolism and the mechanisms through which leptin affects glucose homeostasis have not been fully elucidated. We gene...
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Article
Open AccessSuppression of hyperinsulinaemia in growing female mice provides long-term protection against obesity
Hyperinsulinaemia is associated with obesity but its causal role in the onset of obesity remains controversial. In this study, we tested the hypothesis that transient attenuation of diet-induced insulin hypers...
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Article
Open Access14-3-3ζ coordinates adipogenesis of visceral fat
The proteins that coordinate complex adipogenic transcriptional networks are poorly understood. 14-3-3ζ is a molecular adaptor protein that regulates insulin signalling and transcription factor networks. Here ...
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Article
Leptin induces fasting hypoglycaemia in a mouse model of diabetes through the depletion of glycerol
Leptin has profound glucose-lowering effects in rodent models of type 1 diabetes, and is currently being tested clinically to treat this disease. In addition to reversing hyperglycaemia, leptin therapy correct...
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Article
PWD/PhJ mice have a genetically determined increase in nutrient-stimulated insulin secretion
PWD/PhJ (PWD) is a wild-derived inbred mouse strain unrelated to commonly studied strains, such as C57BL/6J (B6). A chromosome substitution panel with PWD chromosomes transferred into the B6 background is comm...
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Article
Insulin induces long-term depression of ventral tegmental area dopamine neurons via endocannabinoids
The authors show that insulin induces long-term depression of excitatory synapses onto ventral tegmental area (VTA) neurons in rodents, which requires endocannabinoid-mediated presynaptic inhibition of glutama...
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Article
Open AccessDiabetes genes identified by genome-wide association studies are regulated in mice by nutritional factors in metabolically relevant tissues and by glucose concentrations in islets
Genome-wide association studies (GWAS) have recently identified many new genetic variants associated with the development of type 2 diabetes. Many of these variants are in introns of known genes or between kno...
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Article
Open AccessNutritional regulation of genome-wide association obesity genes in a tissue-dependent manner
Genome-wide association studies (GWAS) have recently identified several new genetic variants associated with obesity. The majority of the variants are within introns or between genes, suggesting they affect ge...
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Article
Positional cloning of Sorcs1, a type 2 diabetes quantitative trait locus
We previously mapped the type 2 diabetes mellitus-2 locus (T2dm2), which affects fasting insulin levels, to distal chromosome 19 in a leptin-deficient obese F2 intercross derived from C57BL/6 (B6) and BTBR T+ tf/...
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Article
Mutations in ABC1 in Tangier disease and familial high-density lipoprotein deficiency
Genes have a major role in the control of high-density lipoprotein (HDL) cholesterol (HDL-C) levels. Here we have identified two Tangier disease (TD) families, confirmed 9q31 linkage and refined the disease lo...
