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Article
Open AccessSexual dimorphism in bidirectional SR-mitochondria crosstalk in ventricular cardiomyocytes
Calcium transfer into the mitochondrial matrix during sarcoplasmic reticulum (SR) Ca2+ release is essential to boost energy production in ventricular cardiomyocytes (VCMs) and match increased metabolic demand. Mi...
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Elements of Teratology
Birth defects are not a rare phenomenon, and, in most cases, are not related to environmental agents. A baseline risk for malformation of 1–3% is commonly used as a reference frame for evaluating the teratogen...
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Article
Open AccessFactors associated with medical complications after body art among Israeli adults: a retrospective study
Body-art, including tattoos and piercings, is steadily increasing world-wide but with relatively limited reporting of adverse outcomes. The objective of the present study was to identify correlates that would ...
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Article
Chiral Transplacental Pharmacokinetics of Fexofenadine: Impact of P-Glycoprotein Inhibitor Fluoxetine Using the Human Placental Perfusion Model
Fexofenadine is a well-identified in vivo probe substrate of P-glycoprotein (P-gp) and/or organic anion transporting polypeptide (OATP). This work aimed to investigate the transplacental pharmacokinetics of fexof...
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Article
Open AccessMachine learning algorithm for early detection of end-stage renal disease
End stage renal disease (ESRD) describes the most severe stage of chronic kidney disease (CKD), when patients need dialysis or renal transplant. There is often a delay in recognizing, diagnosing, and treating ...
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Article
RETRACTED ARTICLE: Fetal Safety of Dydrogesterone Exposure in the First Trimester of Pregnancy
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Expression of Concern to: Fetal Safety of Dydrogesterone Exposure in the First Trimester of Pregnancy
The Editor-in-Chief of Clinical Drug Investigation has become aware that the original article contains a number of errors and inconsistencies.
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Article
Open AccessOral cavity swabbing for diagnosis of group a Streptococcus: a prospective study
Throat pain is a common complaint in the ambulatory setting. Diagnosis of group A Streptococcus is made with a culture, molecular test or a rapid antigen detection test from the tonsils or the posterior pharyn...
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Article
Open AccessThe use of cannabis for Hyperemesis Gravidarum (HG)
Hyperemesis Gravidarum (HG) responds only partially to standard antiemetic medications. Cannabis has been known to possess antiemetic effects and there are several medicinal cannabinoids used as anti -emetics ...
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Article
Open AccessThe prevalence of iron deficiency anemia among African asylum seeking children residing in Tel Aviv
It has been the impression of pediatricians at the Terem Clinic for African asylum seekers in Tel Aviv that they encounter large numbers of anemic children.
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Open AccessAssociations of sociodemographic and clinical factors with perinatal depression among Israeli women: a cross-sectional study
Perinatal depression is a common problem that affects about 18% of women worldwide, though the heterogeneity between countries is great. The aims of this study were to assess the prevalence of perinatal depres...
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Article
Open AccessShort-Long Heart Rate Variation Increases Dispersion of Action Potential Duration in Long QT Type 2 Transgenic Rabbit Model
The initiation of polymorphic ventricular tachycardia in long QT syndrome type 2 (LQT2) has been associated with a characteristic ECG pattern of short-long RR intervals. We hypothesize that this characteristic...
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Article
Oral Contraceptives and Neutropenia: A Population-Based Cohort Study
Oral contraceptives (OCs) are one of the most commonly used classes of drugs worldwide. A case of neutropenia and associated infections in a young woman using OCs that settled after discontinuation and reappea...
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Article
Response to: “Comment on: Drugs that Can Kill a Toddler with One Tablet or Teaspoonful: A 2018 Updated List”
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Article
Personal clinical history predicts antibiotic resistance of urinary tract infections
Antibiotic resistance is prevalent among the bacterial pathogens causing urinary tract infections. However, antimicrobial treatment is often prescribed ‘empirically’, in the absence of antibiotic susceptibilit...
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Article
Comparison of sublingual vs. intramuscular administration of vitamin B12 for the treatment of patients with vitamin B12 deficiency
There are several methods to treat vitamin B12 deficiency (VB12d): intramuscular (IM), oral, sublingual (SL), and intranasal vitamin B12 (VB12) preparations. Large studies comparing the efficacy of SL vs. IM s...
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Article
Chronic Use of β-Blockers and the Risk of Parkinson’s Disease
Most patients with Parkinson’s disease exhibit intracellular accumulation of the α-synuclein protein encoded by the α-synuclein gene. It was recently shown that β2-adrenoreceptor agonists downregulate this gene, ...
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Article
Open AccessPrevalence of Fetal Alcohol Exposure by Analysis of Meconium Fatty Acid Ethyl Esters; A National Canadian Study
Our study aimed to estimate the prevalence of heavy fetal alcohol exposure through the analysis of meconium FAEEs as an objective biomarker of fetal exposure. We conducted a study on meconium samples collected...
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Article
Drugs that Can Kill a Toddler with One Tablet or Teaspoonful: A 2018 Updated List
Young children may be accidentally exposed to adult dose forms of medications, some of which can be fatal, even with a single dose. As numerous new medications have been introduced, we herein update a 2004 lis...
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Article
Dose-Dependent Teratology in Humans: Clinical Implications for Prevention
Since the inception of clinical teratology, the vast majority of scientific work has focused on identification of drugs and environmental agents causing malformations in humans as a dichotomous variable (i.e. ...
