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Article
Genetic architecture of cardiac dynamic flow volumes
Cardiac blood flow is a critical determinant of human health. However, the definition of its genetic architecture is limited by the technical challenge of capturing dynamic flow volumes from cardiac imaging at...
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Article
Open AccessReproducibility in the UK biobank of genome-wide significant signals discovered in earlier genome-wide association studies
With the establishment of large biobanks, discovery of single nucleotide variants (SNVs, also known as single nucleotide polymorphisms (SNVs)) associated with various phenotypes has accelerated. An open questi...
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Article
Improving reporting standards for polygenic scores in risk prediction studies
Polygenic risk scores (PRSs), which often aggregate results from genome-wide association studies, can bridge the gap between initial discovery efforts and clinical applications for the estimation of disease ri...
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Article
Multimodality Imaging for Risk Assessment of Inherited Cardiomyopathies
This review summarizes the evidence concerning the imaging techniques and features to (a) diagnose and (b) risk stratify patients with, or at risk of, inherited cardiomyopathies. The inherited cardiomyopathies...
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Article
Open AccessPractice variation in the use of tests in UK primary care: a retrospective analysis of 16 million tests performed over 3.3 million patient years in 2015/16
The UK’s National Health Service (NHS) is currently subject to unprecedented financial strain. The identification of unnecessary healthcare resource use has been suggested to reduce spending. However, there is...
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Article
Open AccessThe map** of cancer incidence and mortality trends in the UK from 1980–2013 reveals a potential for overdiagnosis
The incidence of cancer in the United Kingdom has increased significantly over the last four decades. The aim of this study was to examine trends in UK cancer incidence and mortality by cancer site and assess ...
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Article
Open AccessAuthor Correction: Variation in diagnostic test requests and outcomes: a preliminary metric for OpenPathology.net
A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper.
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Article
Open AccessVariation in diagnostic test requests and outcomes: a preliminary metric for OpenPathology.net
Efforts to reduce healthcare costs have led to the development of metrics to identify unwarranted variation in care. Previous work assessing diagnostic tests is limited, despite their substantial contribution ...
