19 Result(s)
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Theresia M. Schnurr
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Open AccessAuthor Correction: Trans-ancestral genome-wide association study of longitudinal pubertal height growth and shared heritability with adult health outcomes
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Genetic architecture of cardiac dynamic flow volumes
Cardiac blood flow is a critical determinant of human health. However, the definition of its genetic architecture is limited by the technical challenge of capturing dynamic flow volumes from cardiac imaging at...
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Open AccessTrans-ancestral genome-wide association study of longitudinal pubertal height growth and shared heritability with adult health outcomes
Pubertal growth patterns correlate with future health outcomes. However, the genetic mechanisms mediating growth trajectories remain largely unknown. Here, we modeled longitudinal height growth with Super-Impo...
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Open AccessThe influence of insulin-related genetic variants on fetal growth, fetal blood flow, and placental weight in a prospective pregnancy cohort
The fetal insulin hypothesis proposes that low birthweight and type 2 diabetes (T2D) in adulthood may be two phenotypes of the same genotype. In this study we aimed to explore this theory further by testing th...
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Open AccessG protein-coupled receptor 151 regulates glucose metabolism and hepatic gluconeogenesis
Human genetics has been instrumental in identification of genetic variants linked to type 2 diabetes. Recently a rare, putative loss-of-function mutation in the orphan G-protein coupled receptor 151 (GPR151) was ...
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Open AccessIntegration of genetic colocalizations with physiological and pharmacological perturbations identifies cardiometabolic disease genes
Identification of causal genes for polygenic human diseases has been extremely challenging, and our understanding of how physiological and pharmacological stimuli modulate genetic risk at disease-associated lo...
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Open AccessSmoking during pregnancy is associated with child overweight independent of maternal pre-pregnancy BMI and genetic predisposition to adiposity
High maternal body mass index (BMI) and smoking during pregnancy are risk factors for child overweight. Maternal smoking tends to reduce her BMI and the association of smoking with child overweight may be conf...
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Open AccessDo genetic risk scores for childhood adiposity operate independent of BMI of their mothers?
Genetic predisposition and maternal body mass index (BMI) are risk factors for childhood adiposity, defined by either BMI or overweight. We aimed to investigate whether childhood-specific genetic risk scores (...
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Open AccessPhysical activity attenuates postprandial hyperglycaemia in homozygous TBC1D4 loss-of-function mutation carriers
The common muscle-specific TBC1D4 p.Arg684Ter loss-of-function variant defines a subtype of non-autoimmune diabetes in Arctic populations. Homozygous carriers are characterised by elevated postprandial glucose an...
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Open AccessThe effects of a 2-year physical activity and dietary intervention on plasma lipid concentrations in children: the PANIC Study
We studied the effects of a physical activity and dietary intervention on plasma lipids in a general population of children. We also investigated how lifestyle changes contributed to the intervention effects.
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Open AccessObesity treatment effect in Danish children and adolescents carrying Melanocortin-4 Receptor mutations
To determine the prevalence of Melanocortin-4 Receptor (MC4R) mutations in a cohort of children and adolescents with overweight or obesity and to determine whether treatment responses differed between carriers an...
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Open AccessA 2 year physical activity and dietary intervention attenuates the increase in insulin resistance in a general population of children: the PANIC study
We studied for the first time the long-term effects of a combined physical activity and dietary intervention on insulin resistance and fasting plasma glucose in a general population of predominantly normal-wei...
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Predictors of weight loss after bariatric surgery—a cross-disciplinary approach combining physiological, social, and psychological measures
Bariatric surgery leads to a substantial weight loss (WL), however, a subset of patients undergoing surgery fails to achieve adequate WL. The reason for the individual variation in WL remains unexplained. Usin...
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Obesity, unfavourable lifestyle and genetic risk of type 2 diabetes: a case-cohort study
We aimed to investigate whether the impact of obesity and unfavourable lifestyle on type 2 diabetes risk is accentuated by genetic predisposition.
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Open AccessThe influence of transmitted and non-transmitted parental BMI-associated alleles on the risk of overweight in childhood
Overweight in children is strongly associated with parental body mass index (BMI) and overweight. We assessed parental transmitted and non-transmitted genetic contributions to overweight in children from the D...
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Open AccessGenetic predisposition to higher body fat yet lower cardiometabolic risk in children and adolescents
Most obese children show cardiometabolic impairments, such as insulin resistance, dyslipidemia, and hypertension. Yet some obese children retain a normal cardiometabolic profile. The mechanisms underlying this...
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Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors
Birth weight variation is influenced by fetal and maternal genetic and non-genetic factors, and has been reproducibly associated with future cardio-metabolic health outcomes. In expanded genome-wide associatio...
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Open AccessAn adult-based insulin resistance genetic risk score associates with insulin resistance, metabolic traits and altered fat distribution in Danish children and adolescents who are overweight or obese
A genetic risk score (GRS) consisting of 53 insulin resistance variants (GRS53) was recently demonstrated to associate with insulin resistance in adults. We speculated that the GRS53 might already associate with ...
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Open AccessLarge-scale GWAS identifies multiple loci for hand grip strength providing biological insights into muscular fitness
Hand grip strength is a widely used proxy of muscular fitness, a marker of frailty, and predictor of a range of morbidities and all-cause mortality. To investigate the genetic determinants of variation in grip...
