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  1. Article

    The Coronavirus Standards Working Group’s roadmap for improved population testing

    Tim Mercer, Neil Almond, Michael A. Crone, Patrick S. G. Chain… in Nature Biotechnology (2022)

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  2. Article

    Open Access

    Cost Effectiveness of Sequencing 34 Cancer-Associated Genes as an Aid for Treatment Selection in Patients with Metastatic Melanoma

    To determine whether a next-generation sequencing (NGS) panel of 34 cancer-associated genes would cost-effectively aid in the treatment selection for patients with metastatic melanoma, compared with a single-s...

    Yonghong Li, Lance A. Bare, Richard A. Bender… in Molecular Diagnosis & Therapy (2015)

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  3. Article

    Open Access

    Genetic Testing for Early Detection of Individuals at Risk of Coronary Heart Disease and Monitoring Response to Therapy: Challenges and Promises

    Coronary heart disease (CHD) often presents suddenly with little warning. Traditional risk factors are inadequate to identify the asymptomatic high-risk individuals. Early identification of patients with subcl...

    H. Robert Superko, Robert Roberts, Arthur Agatston… in Current Atherosclerosis Reports (2011)

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    Article

    Proportionally more deleterious genetic variation in European than in African populations

    The analysis of genome-wide patterns of variation in human populations can provide genetic evidence of patterns of human migration and adaptation across the world. Two contrasting papers in this issue illustra...

    Kirk E. Lohmueller, Amit R. Indap, Steffen Schmidt, Adam R. Boyko… in Nature (2008)

  5. No Access

    Article

    Natural selection on protein-coding genes in the human genome

    Are we still evolving? The simple answer is yes. A comparison of the sequences of over 11,000 genes from 39 human individuals and from chimpanzees reveals more than 1,139 genes that show evidence of either pos...

    Carlos D. Bustamante, Adi Fledel-Alon, Scott Williamson, Rasmus Nielsen… in Nature (2005)

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    Chapter

    Diagnosis of HIV Infection and the Polymerase Chain Reaction (PCR)

    Since the description of the first cases of acquired immunodeficiency syndrome (AIDS) in 1981, the global impact of this new epidemic has been dramatic. By July, 1993, more than 150 countries had reported over...

    Gerald Schochetman, John J. Sninsky in Applied Virology Research (1994)

  7. Chapter

    Direct Detection of HIV Infection Using Nucleic Amplification Techniques

    Although infectious viral particles of human immunodeficiency virus (HIV) encapsidate single-stranded RNA (ssRNA) as the genetic information, the viral life cycle includes a compulsory conversion to double-str...

    Gerald Schochetman, John J. Sninsky in AIDS Testing (1994)

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    Chapter

    Direct Detection of Human Immunodeficiency Virus Infection Using the Polymerase Chain Reaction

    Although infectious viral particles of human immunodeficiency virus (HIV) encapsidate single-stranded RNA (ssRNA) as the genetic information, the viral life cycle includes a compulsory conversion to doublestra...

    Gerald Schochetman, John J. Sninsky in AIDS Testing (1992)

  9. No Access

    Chapter

    Application of PCR to the Detection of Human Infectious Diseases

    The polymerase chain reaction (PCR)1,2 has revolutionized the detection of bacterial, fungal, and viral pathogens. The targeted amplification of nucleic acid sequences provides not only dramatic increases in the ...

    Shirley Kwok, John J. Sninsky in PCR Technology (1989)

  10. No Access

    Article

    Cloning and endonuclease map** of the hepatitis B viral genome

    THE virus that causes hepatitis B, or serum hepatitis, seems to infect only humans in nature, and experimental infection has been achieved in only a few additional mammals. The limited host range of the hepati...

    JOHN J. SNINSKY, ALEEM SIDDIQUI, WILLIAM S. ROBINSON, STANLEY N. COHEN in Nature (1979)