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Chapter
The Role of Genetics in Preventive Cardiology: Utility of Clinically Available Genetic Tests
Genetic testing can help fill an unmet clinical need in the specialty of preventive cardiology. While significant advances have been made over the past two decades in identification and treatment of individual...
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Article
Open AccessEffects of weight change on apolipoprotein B-containing emerging atherosclerotic cardiovascular disease (ASCVD) risk factors
Non-high-density (HDL)-cholesterol, low-density lipoprotein (LDL)-particle number, apolipoprotein B, lipoprotein(a) (Lp(a)), and small-dense (sdLDL) and large-buoyant (lbLDL) LDL-subfractions are emerging apo ...
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Article
Open AccessOmega-3 Fatty Acid Blood Levels Clinical Significance Update
The potential benefit of fish oil (omega-3 fatty acids) consumption to reduce cardiovascular disease (CVD) risk remains controversial. Some investigations report reduced CVD risk associated with fish or fish o...
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Article
Genetics and Personalized Medicine—a Role in Statin Therapy?
Pharmacogenetics uses the genetic variation in metabolic pathways to identify groups of patients who may respond differently in terms of therapeutic and adverse effects. Much clinical interest lies in drug met...
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Article
Open AccessGenetic Testing for Early Detection of Individuals at Risk of Coronary Heart Disease and Monitoring Response to Therapy: Challenges and Promises
Coronary heart disease (CHD) often presents suddenly with little warning. Traditional risk factors are inadequate to identify the asymptomatic high-risk individuals. Early identification of patients with subcl...
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Chapter
The Statin Response Gene: KIF6
For over two decades, substantial National efforts have been directed toward reducing blood cholesterol levels of the American population with the intent of reducing the burden of cardiovascular events. This ...
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Article
Is it LDL particle size or number that correlates with risk for cardiovascular disease?
The role of low-density lipoprotein cholesterol (LDL-C) in the pathogenesis of cardiovascular disease (CVD) and the clinical benefit of lowering LDL-C in high-risk patients is well established. What remains co...
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Chapter
Lipoproteins and Oxidation: Clinical Aspects of Lipoprotein Metabolism and Oxidation
Atherosclerosis is the result of complex gene/environment interactions and include disorders of the lipoprotein system [1]. Well intentioned focus on the detection and treatment of elevated LDLC has resulted i...
