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Boekbesprekingen
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Abstracts of papers
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Abstracts of papers Pharmaceutical and biomedical analysis meeting
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Abstracts of papers Clinical Pharmacological meeting
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Human pharmacokinetics of orally administered strontium
Pharmacokinetics of orally administered SrCl2 (2.5 mmol), were studied in six healthy male volunteers. In the overall plasma concentration time (C-t) curves, two absorption phases were observed due to two dominan...
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The effect of pamidronate on bone histomorphometry in osteoporotic patients
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Effects of continuously combined hormone replacement therapy on the biochemical markers of bone turnover
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A test parameter representative for bioavailability of calcium and strontium in rats: Effect of intervention
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The value of measuring a single biochemical bone marker in the prediction of bone mineral density
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The use of etidronate and calcium versus calcium alone in the treatment of postmenopausal osteopenia: Results of three years of treatment
The purpose of this open, prospective, controlled, randomized trial was to study the effect of intermittent, cyclic etidronate on the bone mass of osteoporotic postmenopausal women with or without fractures. E...
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Bone Histomorphometric Evaluation of Pamidronate Treatment in Clinically Manifest Osteoporosis
The effect of pamidronate therapy on bone histology was studied in patients with osteoporosis with at least one vertebral fracture in a randomized, double-masked, placebo-controlled, multi-center trial. Patie...
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Camurati–Engelmann disease (progressive diaphyseal dysplasia) in a Moroccan family
We report on a 46-year-old mother of Moroccan origin, suffering mainly from painful, swollen legs, and her 26-year-old son who had experienced intense pain in his legs, without fever, for approximately 3 years...
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Open AccessThe Global Longitudinal Study of Osteoporosis in Women (GLOW): rationale and study design
The Global Longitudinal study of Osteoporosis in Women (GLOW) is a prospective cohort study involving 723 physicians and 60,393 women subjects ≥55 years. The data will provide insights into the management of f...
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Spine radiographs to improve the identification of women at high risk for fractures
In women older than 60 years with clinical risk factors for osteoporosis but without osteoporosis based on bone mineral density (T-score ≥ −2.5), a systematic survey with X-rays of the spine identified previously...
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Open AccessFailure to perceive increased risk of fracture in women 55 years and older: the Global Longitudinal Study of Osteoporosis in Women (GLOW)
We compared self-perception of fracture risk with actual risk among 60,393 postmenopausal women aged ≥55 years, using data from the Global Longitudinal Study of Osteoporosis in Women (GLOW). Most postmenopausa...
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Open AccessAdherence and profile of non-persistence in patients treated for osteoporosis—a large-scale, long-term retrospective study in The Netherlands
We analyzed 12-month compliance for all ten oral osteoporosis drugs in the Netherlands by medication possession ratio (MPR ≥ 80%) in 105,506 patients, and persistence in 8,626 starters indicated high MPR (91%)...
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Regional and age-related variations in the proportions of hip fractures and major fractures among postmenopausal women: the Global Longitudinal Study of Osteoporosis in Women
We examined variations in proportions of hip fractures and major fractures among postmenopausal women using the Global Longitudinal Study of Osteoporosis in Women (GLOW). The proportion of major fractures that...
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Burden of non-hip, non-vertebral fractures on quality of life in postmenopausal women
Among 50,461 postmenopausal women, 1,822 fractures occurred (57% minor non-hip, non-vertebral [NHNV], 26% major NHNV, 10% spine, 7% hip) over 1 year. Spine fractures had the greatest detrimental effect on EQ-5...
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Non-hip, non-spine fractures drive healthcare utilization following a fracture: the Global Longitudinal Study of Osteoporosis in Women (GLOW)
We evaluated healthcare utilization associated with treating fracture types in >51,000 women aged ≥55 years. Over the course of 1 year, there were five times more non-hip, non-spine fractures than hip or spine...
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Disease-specific perception of fracture risk and incident fracture rates: GLOW cohort study
Accurate patient risk perception of adverse health events promotes greater autonomy over, and motivation towards, health-related lifestyles.