Résumé
Les tumeurs germinales malignes sont localisées dans le médiastin dans 1 % à 3 % des cas. Ces tumeurs correspondent à 50 % à 70 % des tumeurs germinales malignes extragonadiques, et à 13 % des tumeurs médiastinales dans leur ensemble (1). Les différents sous-types de tumeurs germinales malignes peuvent être retrouvés au niveau médiastinal, avec d’une part les tumeurs germinales non séminomateuses (carcinome embryonnaire, tumeur du sac vitellin, choriocarcinome, tumeur composite), et d’autre part les séminomes (1). Leurs aspects anatomopathologies sont similaires à ceux observés au niveau gonadique (1). Les tumeurs germinales non séminomateuses sont deux fois plus fréquentes au niveau médiastinal que les séminomes, alors qu’elles ne représentent que 55 % des tumeurs germinales gonadiques (1).
Références
Wick MR, Perlman EJ, Orazi A, et al. (2004) Germ cell tumours of the mediastinum. In: Travis WB, Brambilla A, Muller-Hermelinck HK, Harris CC, World Health Organization classification of tumours. Pathology and Genetics of Tumours of the lung, Pleura, Thymus and heart. IARC Press: Lyon, p 198–201
Hartmann JT, Nichols CR, Droz JP, et al. (2000) Hematologic disorders associated with primary mediastinal nonseminomatous germ cell tumors. J Natl Cancer Inst 92: 54–61
Daugaard G, Rorth M, von der Maase H, Skakkebaek NE (1992) Management of extragonadal germ-cell tumors and the significance of bilateral testicular biopsies. Ann Oncol 3: 283–9
Wright CD, Kesler KA, Nichols CR, et al. (1990) Primary mediastinal nonseminomatous germ cell tumors. Results of a multimodality approach. J Thorac Cardiovasc Surg 99: 210–7
Lemarie E, Assouline PS, Diot P, et al. (1992) Primary mediastinal germ cell tumors. Results of a French retrospective study. Chest 102: 1477–83
Vuky J, Bains M, Bacik J, et al. (2001) Role of postchemotherapy adjunctive surgery in the management of patients with nonseminoma arising from the mediastinum. J Clin Oncol 19: 682–8
Knapp RH, Hurt RD, Payne WS, et al. (1985) Malignant germ cell tumors of the mediastinum. J Thorac Cardiovasc Surg 89: 82–9
Moran CA, Suster S, Koss MN (1997) Primary germ cell tumors of the mediastinum: III. Yolk sac tumor, embryonal carcinoma, choriocarcinoma, and combined nonteratomatous germ cell tumors of the mediastinum—a clinicopathologic and immunohistochemical study of 64 cases. Cancer 80: 699–707
Moran CA, Suster S, Przygodzki RM, Koss MN (1997) Primary germ cell tumors of the mediastinum: II. Mediastinal seminomas—a clinicopathologic and immunohistochemical study of 120 cases. Cancer 80: 691–8
Bokemeyer C, Droz JP, Horwich A, et al. (2001) Extragonadal seminoma: an international multicenter analysis of prognostic factors and long term treatment outcome. Cancer 91: 1394–401
Nichols CR, Heerema NA, Palmer C, et al. (1987) Klinefelter’s syndrome associated with mediastinal germ cell neoplasms. J Clin Oncol 5: 1290–4
De Giorgi U, Pupi A, Fiorentini G, et al. (2005) FDG-PET in the management of germ cell tumor. Ann Oncol 16S4: iv90–iv94
International Germ Cell Cancer Collaborative Group (1997) International Germ Cell Consensus Classification: a prognostic factor-based staging system for metastatic germ cell cancers. J Clin Oncol 15: 594–603
Bokemeyer C, Nichols CR, Droz JP, et al. (2002) Extragonadal germ cell tumors of the mediastinum and retroperitoneum: results from an international analysis. J Clin Oncol 20: 1864–73
Hartmann JT, Nichols CR, Droz JP, et al. (2002) Prognostic variables for response and outcome in patients with extragonadal germ-cell tumors. Ann Oncol 13: 1017–28
Bukowski RM, Wolf M, Kulander BG, et al. (1993) Alternating combination chemotherapy in patients with extragonadal germ cell tumors. A Southwest Oncology Group study. Cancer 71: 2631–8
Walsh GL, Taylor GD, Nesbitt JC, Amato RJ (2000) Intensive chemotherapy and radical resections for primary nonseminomatous mediastinal germ cell tumors. Ann Thorac Surg 69: 337–43
Ganjoo KN, Rieger KM, Kesler KA, et al. (2000) Results of modern therapy for patients with mediastinal nonseminomatous germ cell tumors. Cancer 88: 1051–6
Kesler KA, Rieger KM, Ganjoo KN, et al. (1999) Primary mediastinal nonseminomatous germ cell tumors: the influence of postchemotherapy pathology on long-term survival after surgery. J Thorac Cardiovasc Surg 118: 692–700
Fizazi K, Culine S, Droz JP, et al. (1998) Primary mediastinal nonseminomatous germ cell tumors: results of modern therapy including cisplatin-based chemotherapy. J Clin Oncol 16: 725–32
Fizazi K, Tjulandin S, Salvioni R, et al. (2001) Viable malignant cells after primary chemotherapy for disseminated nonseminomatous germ cell tumors: prognostic factors and role of postsurgery chemotherapy—results from an international study group. J Clin Oncol 19: 2647–57
Broun ER, Nichols CR, Einhorn LH, Tricot GJ (1991) Salvage therapy with high-dose chemotherapy and autologous bone marrow support in the treatment of primary nonseminomatous mediastinal germ cell tumors. Cancer 68: 1513–5
Jain KK, Bosl GJ, Bains MS, Whitmore WF, et al. (1984) The treatment of extragonadal seminoma. J Clin Oncol 2: 820–7
Afifi HY, Bosl GJ, Burt ME (1997) Mediastinal growing teratoma syndrome. Ann Thorac Surg 64: 359–62
Author information
Authors and Affiliations
Rights and permissions
Copyright information
© 2010 Springer-Verlag France, Paris
About this chapter
Cite this chapter
Girard, N., Lemarié, É., Cordier, JF., Droz, JP. (2010). Médiastin. In: Tumeurs malignes rares. Springer, Paris. https://doi.org/10.1007/978-2-287-72070-3_43
Download citation
DOI: https://doi.org/10.1007/978-2-287-72070-3_43
Publisher Name: Springer, Paris
Print ISBN: 978-2-287-72069-7
Online ISBN: 978-2-287-72070-3