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Chapter
Physical Rationale for Proton Therapy and Elements to Build a Clinical Center
In this chapter we present:
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The physical bases of proton therapy, going from microscopic concepts to macroscopic features
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Article
High-dose busulfan and thiotepa followed by autologous stem cell transplantation (ASCT) in previously irradiated medulloblastoma patients: high toxicity and lack of efficacy
We previously demonstrated that Busulfan–Thiotepa (Bu–Thio) and ASCT effectively treated patients with locally relapsed medulloblastoma after surgery and conventional chemotherapy. We thus evaluated the admini...
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Article
Open AccessOutcome of flat bone sarcomas (other than Ewing's) in children and adolescents: a study of 25 cases
We analysed the clinical features and outcome of young patients with non-Ewing's flat bone sarcoma treated during the era of contemporary chemotherapy. The characteristics and outcome of 25 patients (15 males ...
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Article
Open AccessNeuropsychological outcome in children with optic pathway tumours when first-line treatment is chemotherapy
Standard treatment of optic pathways gliomas consists of radiotherapy and surgery when feasible. Owing to the toxicity of irradiation, chemotherapy has emerged as an interesting therapeutic option, especially ...
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Chapter and Conference Paper
Patterns of Relapse Following Focal Irradiation of Intracranial Germinoma: Critical Review of TGM-TC90 SFOP protocol
In the SFOP protocol TGM-TC90 for localised tumours, craniospinal (CS) prophylactic radiotherapy fields were replaced by carboplatin-based chemotherapy together with focal irradiation of the initial tumour vol...
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Article
Radiation therapy in the management of childhood brain tumors
Radiation therapy (RT) still plays a major role in the management of intracranial malignancies, together with surgical resection and, more recently, chemotherapy. This is a review of the experience with fracti...
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Article
Clinical applications of proton therapy
Proton therapy offers potentially considerable advantages in the management of slow-growing, poorly resectable or non-resectable tumors resistant to x-rays and located close to critical radiosensitive anatomic...
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Article
New particles in radiotherapy: An introduction
Since the discovery of x-rays and radioactivity, the radiotherapeutic management of malignancy has seen numerous spectacular improvements. Beside the widely used photons and electrons, one area of particular i...
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Chapter
Tumours of the Kidney
This chapter discusses malignant tumours of the kidney; it therefore excludes the subject of benign renal tumours, which are principally cystic lesions and require surgery only when they are unilateral. The ma...
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Article
Brain tumours under the age of three. The price of survival
Between 1975 and 1989, 98 children with brain tumours under the age of three at time of diagnosis were entered into a retrospective study. Twenty of them are alive and free of tumour more than five years after...
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Article
Enhanced cutaneous radiation effects following high-dose busulfan therapy
Fifteen patients received irradiation after combined chemotherapy with high-dose busulfan followed by autologous or allogeneic bone marrow transplantation. Of nine patients irradiated between day 30 and day 70...