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Article
Open AccessNo topoisomerase I alteration in a neuroblastoma model with in vivo acquired resistance to irinotecan
CPT-11 (irinotecan) is a DNA-topoisomerase I inhibitor with preclinical activity against neuroblastoma (NB) xenografts. The aim was to establish in vivo an NB xenograft resistant to CPT-11 in order to study the r...
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Article
Open AccessBilateral germ-cell tumours: 22-year experience at the Institut Gustave Roussy
The aim of this study was to describe the incidence, clinical and histological characteristics, treatment and long-term follow-up of bilateral germ-cell tumours (BGCT) of the testis in order to determine in wh...
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Article
Open AccessComparative genomic hybridization detects many recurrent imbalances in central nervous system primitive neuroectodermal tumours in children
A series of 23 children with primitive neuroectodermal tumours (PNET) were analysed with comparative genomic hybridization (CGH). Multiple chromosomal imbalances have been detected in 20 patients. The most fre...
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Article
Open AccessBusulphan is active against neuroblastoma and medulloblastoma xenografts in athymic mice at clinically achievable plasma drug concentrations
High-dose busulphan-containing chemotherapy regimens have shown high response rates in children with relapsed or refractory neuroblastoma, Ewing’s sarcoma and medulloblastoma. However, the anti-tumour activity...
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Article
Brain tumours under the age of three. The price of survival
Between 1975 and 1989, 98 children with brain tumours under the age of three at time of diagnosis were entered into a retrospective study. Twenty of them are alive and free of tumour more than five years after...
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Article
Primary breast sarcoma: A review of 33 cases with immunohistochemistry and prognostic factors
The clinical and pathological features of 33 previously untreated patients with primary breast sarcoma were retrospectively analysed to evaluate the prognostic significance of histologic variables on survival....
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Article
Invasive apocrine carcinoma of the breast: A long term follow-up study of 34 cases
We have reviewed the morpho-functional criteria for infiltrating apocrine carcinomas of the breast and analysed long term follow-up of this entity. Thirty-four cases of pure apocrine carcinomas were retrieved ...