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  1. No Access

    Article

    Atomic structure of the ectodomain from HIV-1 gp41

    Fusion of viral and cellular membranes by the envelope glyco-protein gp120/gp41 effects entry of HIV-1 into the cell. The precursor, gp160, is cleaved post-translationally into gp120 and gp41 (refs 1,2), which...

    W. Weissenhorn, A. Dessen, S. C. Harrison, J. J. Skehel, D. C. Wiley in Nature (1997)

  2. No Access

    Article

    Amantadine blocks the channel

    J. J. Skehel in Nature (1992)

  3. No Access

    Article

    Structure of the influenza virus haemagglutinin complexed with its receptor, sialic acid

    The three-dimensional structures of influenza virus haemagglutinins complexed with cell receptor analogues show sialic acids bound to a pocket of conserved amino acids surrounded by antibody-binding sites. Sia...

    W. Weis, J. H. Brown, S. Cusack, J. C. Paulson, J. J. Skehel, D. C. Wiley in Nature (1988)

  4. No Access

    Article

    Immunology: Are peptides good antigens?

    G. Ada, J. J. Skehel in Nature (1985)

  5. Article

    Three-dimensional structure of an antigenic mutant of the influenza virus haemagglutinin

    Antigenic variation in the haemagglutinin (HA) glycoprotein of influenza virus is associated with recurrent epidemics of respiratory disease in man (for review see ref. 1). We have examined the size of structu...

    M. Knossow, R. S. Daniels, A. R. Douglas, J. J. Skehel, D. C. Wiley in Nature (1984)

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    Article

    Single amino acid substitutions in influenza haemagglutinin change receptor binding specificity

    The haemagglutinin (HA) glycoproteins of influenza virus membranes are responsible for binding viruses to cells by interacting with membrane receptor molecules which contain sialic acid (for review see ref. 1)...

    G. N. Rogers, J. C. Paulson, R. S. Daniels, J. J. Skehel, I. A. Wilson… in Nature (1983)

  7. No Access

    Article

    Influenza A specific cytotoxic T-cell clones that do not recognize viral glycoproteins

    Since the demonstration that murine cytotoxic T cells generated during a secondary immune response to influenza A viruses were composed of cross-reactive and subtype-specific populations1–5, it has become of inte...

    A. R. M. Townsend, J. J. Skehel in Nature (1982)

  8. Article

    Structural identification of the antibody-binding sites of Hong Kong influenza haemagglutinin and their involvement in antigenic variation

    Four ‘antigenic sites’ on the three-dimensional structure of the influenza haemagglutinin are identified. At least one amino acid substitution in each site seems to be required for the production of new epidem...

    D. C. Wiley, I. A. Wilson, J. J. Skehel in Nature (1981)

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  9. No Access

    Article

    Structure of the haemagglutinin membrane glycoprotein of influenza virus at 3 Å resolution

    The haemagglutinin glycoprotein of influenza virus is a trimer comprising two structurally distinct regions: a triple-stranded coiled-coil of α-helices extends 76 Å from the membrane and a globular region of a...

    I. A. Wilson, J. J. Skehel, D. C. Wiley in Nature (1981)

  10. No Access

    Article

    Cytotoxic T cells kill influenza virus infected cells but do not distinguish between serologically distinct type A viruses

    THE molecular basis of recognition and target cell killing by cytotoxic T cells is still unknown. Doherty and Zinkernagel showed that mouse cells infected with lymphocytic choriomeningitis virus can be lysed b...

    H. J. ZWEERINK, S. A. COURTNEIDGE, J. J. SKEHEL, M. J. CRUMPTON… in Nature (1977)