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Chapter
Microtubule-Destabilizing Agents: Structural and Mechanistic Insights from the Interaction of Colchicine and Vinblastine with Tubulin
Microtubules (MTs) are dynamic structures of the eukaryotic cytoskeleton that, during cell division, form the mitotic spindle. Perturbing them leads to mitotic arrest and ultimately to cell death. Consistently...
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Article
Stereospecific reactions and interactions in tri-ortho-thymotide clathrates
The emphasis in this paper is on the interpretation of physicochemical phenomena occurring in tri-ortho-thymotide (TOT) clathrates in the light of crystallographic data.
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Article
Three-dimensional structure of an antigenic mutant of the influenza virus haemagglutinin
Antigenic variation in the haemagglutinin (HA) glycoprotein of influenza virus is associated with recurrent epidemics of respiratory disease in man (for review see ref. 1). We have examined the size of structu...
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Chapter
Studies on the Structure and Activities of Influenza Virus Haemagglutinin
The initial events in infection by influenza virus involve binding of virus to sialic acid residues of glycosylated membrane receptors, endocytosis, and fusion of the membranes of virus and endosome. Virus ads...
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Chapter and Conference Paper
Generation and Amplification of Optically Active Compounds Via Inclusion in Chiral Tri-O-Thymotide Clathrates
Tri-o-thymotide (TOT) forms channel-type and cage-type clathrate inclusion compounds with a wide variety of guest molecules. Since these clathrate crystals are chiral, any single crystal contains different amount...
