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Structure of the haemagglutinin membrane glycoprotein of influenza virus at 3 Å resolution

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Abstract

The haemagglutinin glycoprotein of influenza virus is a trimer comprising two structurally distinct regions: a triple-stranded coiled-coil of α-helices extends 76 Å from the membrane and a globular region of antiparallel β-sheet, which contains the receptor binding site and the variable antigenic determinants, is positioned on top of this stem. Each subunit has an unusual loop-like topology, starting at the membrane, extending 135 Å distally and folding back to enter the membrane.

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Author notes

  1. J. J. Skehel: National Institute for Medical Research, Mill Hill, London NW7 1AA, UK

Authors and Affiliations

  1. Gibbs Laboratory, Harvard University, 12 Oxford Street, Cambridge, Massachusetts, 02138

    I. A. Wilson, J. J. Skehel & D. C. Wiley

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Wilson, I., Skehel, J. & Wiley, D. Structure of the haemagglutinin membrane glycoprotein of influenza virus at 3 Å resolution. Nature 289, 366–373 (1981). https://doi.org/10.1038/289366a0

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