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Tumors overexpressing RNF168 show altered DNA repair and responses to genotoxic treatments, genomic instability and resistance to proteotoxic stress

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  1. Article

    Open Access

    Markers associated with genomic instability, immunogenicity and immune therapy responsiveness in Metaplastic carcinoma of the breast: Expression of γH2AX, pRPA2, P53, PD-L1 and tumor infiltrating lymphocytes in 76 cases

    Metaplastic breast cancer (MpBC) is an aggressive subtype of breast carcinoma that is often resistant to conventional chemotherapy. Therefore, novel treatment strategies are urgently needed. Immune check point...

    S. Voutilainen, P. Heikkilä, J. Bartkova, H. Nevanlinna, C. Blomqvist… in BMC Cancer (2022)

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  2. Article

    Open Access

    Addiction to DUSP1 protects JAK2V617F-driven polycythemia vera progenitors against inflammatory stress and DNA damage, allowing chronic proliferation

    Inflammatory and oncogenic signaling converge in disease evolution of BCR–ABL-negative myeloproliferative neoplasms, clonal hematopoietic stem cell disorders characterized by gain-of-function mutation in JAK2 kin...

    J. Stetka, P. Vyhlidalova, L. Lanikova, P. Koralkova, J. Gursky, A. Hlusi… in Oncogene (2019)

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  3. Article

    Open Access

    SETD2 loss-of-function promotes renal cancer branched evolution through replication stress and impaired DNA repair

    Defining mechanisms that generate intratumour heterogeneity and branched evolution may inspire novel therapeutic approaches to limit tumour diversity and adaptation. SETD2 (Su(var), Enhancer of zeste, Trithorax-d...

    N Kanu, E Grönroos, P Martinez, R A Burrell, X Yi Goh, J Bartkova… in Oncogene (2015)

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