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Article
N-Dephenylated and N-phenyl urinary metabolites of mociprazine (CERM 3517) in beagle dogs after oral administration. A mass spectrometric determination
CERM 3S17 (mociprazine), a new anti-emetic compound, was administered orally to six beagle dogs at 10 mg/kg b.i.d. for four days. Unconjugated urinary metabolites were identified by GC-MS analysis against synt...
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Article
Chronopharmacokinetic and bioequivalence studies of two formulations of trimipramine after oral administration in man
The bioavailability of two oral formulations of trimipramine, tablets and solution, was performed in twelve healthy volunteers, in a cross-over study. Each formulation was administered in the morning after a f...
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Article
Kinetics of metapramine and its demethylated metabolites after single and chronic oral administration in man
The kinetics of metapramine and two of its demethylated metabolites were determined in six normal subjects after oral administration of a single 150 mg dose on day 1 and 3 × 50 mg dose on day 2–6. This study h...