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Article
Open AccessIdentification of transcription factors dictating blood cell development using a bidirectional transcription network-based computational framework
Advanced computational methods exploit gene expression and epigenetic datasets to predict gene regulatory networks controlled by transcription factors (TFs). These methods have identified cell fate determining...
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Article
Open AccessGenetic diversity within leukemia-associated immunophenotype-defined subclones in AML
Acute myeloid leukemia (AML) is a highly heterogeneous disease showing dynamic clonal evolution patterns over time. Various subclones may be present simultaneously and subclones may show a different expansion ...
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Article
C-terminal BRE overexpression in 11q23-rearranged and t(8;16) acute myeloid leukemia is caused by intragenic transcription initiation
Overexpression of the BRE (brain and reproductive organ-expressed) gene defines a distinct pediatric and adult acute myeloid leukemia (AML) subgroup. Here we identify a promoter enriched for active chromatin mark...
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Article
Erratum: miR-194-5p/BCLAF1 deregulation in AML tumorigenesis
Correction to: Leukemia (2017) 31, 2315–2325; doi:10.1038/leu.2017.64; published online 10 March 2017 Following the publication of this article, the authors noted a mistake in the author affiliations. 4. Centr...
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Article
Open AccessmiR-194-5p/BCLAF1 deregulation in AML tumorigenesis
Deregulation of epigenetic mechanisms, including microRNA, contributes to leukemogenesis and drug resistance by interfering with cancer-specific molecular pathways. Here, we show that the balance between miR-1...
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Article
CBFβ-SMMHC regulates ribosomal gene transcription and alters ribosome biogenesis
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Article
Open AccessMLL-AF9 and MLL-AF4 oncofusion proteins bind a distinct enhancer repertoire and target the RUNX1 program in 11q23 acute myeloid leukemia
In 11q23 leukemias, the N-terminal part of the mixed lineage leukemia (MLL) gene is fused to >60 different partner genes. In order to define a core set of MLL rearranged targets, we investigated the genome-wid...
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Article
Open AccessThe oncofusion protein FUS–ERG targets key hematopoietic regulators and modulates the all-trans retinoic acid signaling pathway in t(16;21) acute myeloid leukemia
The ETS transcription factor ERG has been implicated as a major regulator of both normal and aberrant hematopoiesis. In acute myeloid leukemias harboring t(16;21), ERG function is deregulated due to a fusion w...
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Article
Open AccessCBFB–MYH11/RUNX1 together with a compendium of hematopoietic regulators, chromatin modifiers and basal transcription factors occupies self-renewal genes in inv(16) acute myeloid leukemia
Different mechanisms for CBFβ–MYH11 function in acute myeloid leukemia with inv(16) have been proposed such as tethering of RUNX1 outside the nucleus, interference with transcription factor complex assembly an...
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Article
Open AccessGenome-wide functions of PML–RARα in acute promyelocytic leukaemia
PML—RAR (retinoic acid receptor)α is the hallmark protein of acute promyelocytic leukaemia, a highly malignant subtype of acute myeloid leukaemia that accounts for approximately 10% of all AML cases. Recently, se...
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Chapter and Conference Paper
The Role of Histone Modifications in Epigenetic Transitions During Normal and Perturbed Development
Epigenetic mechanisms control eukaryotic development beyond DNA-stored information. DNA methylation, histone modifications and variants, nucleosome remodeling and noncoding RNAs all contribute to the dynamic m...
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Article
Exafs evidence for direct Rh-Tan+ bonding and coverage of the metal particles in a Rh/Ta2O5 SMSI catalyst
An EXAFS investigation showed that the rhodium particles in a Rh/Ta2O5 catalyst were fully reduced and in the ‘normal’ state after reduction in H2 at 523 K. After reduction at 858 K, in the SMSI state, tantalum i...
