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Open AccessIdentification of transcription factors dictating blood cell development using a bidirectional transcription network-based computational framework
Advanced computational methods exploit gene expression and epigenetic datasets to predict gene regulatory networks controlled by transcription factors (TFs). These methods have identified cell fate determining...
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Article
C-terminal BRE overexpression in 11q23-rearranged and t(8;16) acute myeloid leukemia is caused by intragenic transcription initiation
Overexpression of the BRE (brain and reproductive organ-expressed) gene defines a distinct pediatric and adult acute myeloid leukemia (AML) subgroup. Here we identify a promoter enriched for active chromatin mark...
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Article
Exclusion of ABCB8 and ABCB10 as cancer candidate genes in acute myeloid leukemia