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  1. No Access

    Article

    Role and therapeutic potential of dietary ketone bodies in lymph vessel growth

    Lymphatic vessels (LVs), lined by lymphatic endothelial cells (LECs), are indispensable for life1. However, the role of metabolism in LECs has been incompletely elucidated. In the present study, it is reported th...

    Melissa García-Caballero, Annalisa Zecchin, Joris Souffreau in Nature Metabolism (2019)

  2. No Access

    Article

    The role of fatty acid β-oxidation in lymphangiogenesis

    Lymphatic vessels are lined by lymphatic endothelial cells (LECs), and are critical for health. However, the role of metabolism in lymphatic development has not yet been elucidated. Here we report that in tran...

    Brian W. Wong, **ngwu Wang, Annalisa Zecchin, Bernard Thienpont, Ivo Cornelissen in Nature (2017)

  3. Article

    Open Access

    Glycolytic regulation of cell rearrangement in angiogenesis

    During vessel sprouting, endothelial cells (ECs) dynamically rearrange positions in the sprout to compete for the tip position. We recently identified a key role for the glycolytic activator PFKFB3 in vessel s...

    Bert Cruys, Brian W. Wong, Anna Kuchnio, Dries Verdegem in Nature Communications (2016)

  4. Article

    Correction: Corrigendum: PAI-1 mediates the antiangiogenic and profibrinolytic effects of 16K prolactin

    Nat. Med. 20, 741–747 (2014); published online 15 June 2014; corrected after print 25 August 2014 In the version of this article initially published, it was stated that 16K PRL levels are increased in retinopa...

    Khalid Bajou, Stephanie Herkenne, Victor L Thijssen, Salvino D'Amico in Nature Medicine (2015)

  5. Article

    Open Access

    Myocyte enhancer factor 2C function in skeletal muscle is required for normal growth and glucose metabolism in mice

    Skeletal muscle is the most abundant tissue in the body and is a major source of total energy expenditure in mammals. Skeletal muscle consists of fast and slow fiber types, which differ in their energy usage, ...

    Courtney M Anderson, Jianxin Hu, Ralston M Barnes, Analeah B Heidt in Skeletal Muscle (2015)

  6. Article

    Correction: Corrigendum: PAI-1 mediates the antiangiogenic and profibrinolytic effects of 16K prolactin

    Nat. Med. 20, 741–747 (2014); published online 15 June 2014; corrected after print 25 August 2014 In the version of this article initially published, it was stated that 16K PRL levels are increased in retinopa...

    Khalid Bajou, Stephanie Herkenne, Victor L Thijssen, Salvino D'Amico in Nature Medicine (2014)

  7. No Access

    Article

    PAI-1 mediates the antiangiogenic and profibrinolytic effects of 16K prolactin

    The antiangiogenic and profibrinolytic activities of the N-terminal fragment of prolactin, 16K PRL, are mediated by its binding to the protein PAI-1.

    Khalid Bajou, Stephanie Herkenne, Victor L Thijssen, Salvino D'Amico in Nature Medicine (2014)

  8. No Access

    Article

    Impaired myocardial angiogenesis and ischemic cardiomyopathy in mice lacking the vascular endothelial growth factor isoforms VEGF164 and VEGF188

    Peter Carmeliet, Yin-Shan Ng, Dieter Nuyens, Gregor Theilmeier in Nature Medicine (1999)