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Article
Role and therapeutic potential of dietary ketone bodies in lymph vessel growth
Lymphatic vessels (LVs), lined by lymphatic endothelial cells (LECs), are indispensable for life1. However, the role of metabolism in LECs has been incompletely elucidated. In the present study, it is reported th...
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Article
Role of glutamine synthetase in angiogenesis beyond glutamine synthesis
Glutamine synthetase, encoded by the gene GLUL, is an enzyme that converts glutamate and ammonia to glutamine. It is expressed by endothelial cells, but surprisingly shows negligible glutamine-synthesizing activi...
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Article
The role of fatty acid β-oxidation in lymphangiogenesis
Lymphatic vessels are lined by lymphatic endothelial cells (LECs), and are critical for health. However, the role of metabolism in lymphatic development has not yet been elucidated. Here we report that in tran...
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Article
Correction: Corrigendum: Fatty acid carbon is essential for dNTP synthesis in endothelial cells
Nature 520, 192–197 (2015); doi:10.1038/nature14362 We thank our colleagues from the metabolism community (Emile Van Schaftingen and Guido Bommer, University of Louvain, Belgium, and Frans Schuit, University o...
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Article
Fatty acid carbon is essential for dNTP synthesis in endothelial cells
The metabolism of endothelial cells during vessel sprouting remains poorly studied. Here we report that endothelial loss of CPT1A, a rate-limiting enzyme of fatty acid oxidation (FAO), causes vascular sproutin...
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Article
Targeting endothelial cell metabolism: new therapeutic prospects?
Endothelial cells (ECs) line blood vessels and function as a vital conduit for oxygen and nutrients, but can also form vascular niches for various types of stem cells. While mostly quiescent throughout adult l...
