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  1. No Access

    Article

    Mechanisms of CD40-dependent cDC1 licensing beyond costimulation

    CD40 signaling in classical type 1 dendritic cells (cDC1s) is required for CD8 T cell-mediated tumor rejection, but the underlying mechanisms are incompletely understood. Here, we identified CD40-induced genes...

    Renee Wu, Ray A. Ohara, Suin Jo, Tian-Tian Liu, Stephen T. Ferris… in Nature Immunology (2022)

  2. No Access

    Article

    The role of fatty acid β-oxidation in lymphangiogenesis

    Lymphatic vessels are lined by lymphatic endothelial cells (LECs), and are critical for health. However, the role of metabolism in lymphatic development has not yet been elucidated. Here we report that in tran...

    Brian W. Wong, **ngwu Wang, Annalisa Zecchin, Bernard Thienpont, Ivo Cornelissen… in Nature (2017)

  3. Article

    Open Access

    Glycolytic regulation of cell rearrangement in angiogenesis

    During vessel sprouting, endothelial cells (ECs) dynamically rearrange positions in the sprout to compete for the tip position. We recently identified a key role for the glycolytic activator PFKFB3 in vessel s...

    Bert Cruys, Brian W. Wong, Anna Kuchnio, Dries Verdegem… in Nature Communications (2016)

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  4. No Access

    Article

    Metabolism of stromal and immune cells in health and disease

    This Review discusses stromal and immune cell metabolism and its implications for health and disease.

    Bart Ghesquière, Brian W. Wong, Anna Kuchnio, Peter Carmeliet in Nature (2014)