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  1. No Access

    Article

    Generation of a humanized mAce2 and a conditional hACE2 mouse models permissive to SARS-COV-2 infection

    The Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) remains a public health concern and a subject of active research effort. Development of pre-clinical animal models is critical to study viral-ho...

    I-Wen Song, Megan Washington, Carolina Leynes, Jason Hsu… in Mammalian Genome (2024)

  2. No Access

    Article

    Reproductive Outcomes from Maternal Loss of Nlrp2 Are Not Improved by IVF or Embryo Transfer Consistent with Oocyte-Specific Defect

    Nlrp2 encodes a protein of the oocyte subcortical maternal complex (SCMC), required for embryo development. We previously showed that loss of maternal Nlrp2 in mice causes subfertility, smaller litters with birth...

    Sara Arian, Jessica Rubin, Imen Chakchouk, Momal Sharif… in Reproductive Sciences (2021)

  3. No Access

    Article

    A resource of targeted mutant mouse lines for 5,061 genes

    The International Mouse Phenoty** Consortium reports the generation of new mouse mutant strains for more than 5,000 genes, including 2,850 novel null, 2,987 novel conditional-ready and 4,433 novel reporter a...

    Marie-Christine Birling, Atsushi Yoshiki, David J. Adams, Shinya Ayabe… in Nature Genetics (2021)

  4. Article

    Open Access

    Comparative analysis of single-stranded DNA donors to generate conditional null mouse alleles

    The International Mouse Phenoty** Consortium is generating null allele mice for every protein-coding gene in the genome and characterizing these mice to identify gene–phenotype associations. While CRISPR/Cas...

    Denise G. Lanza, Angelina Gaspero, Isabel Lorenzo, Lan Liao, ** Zheng… in BMC Biology (2018)

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  5. Article

    Open Access

    Erratum: Maternally expressed NLRP2 links the subcortical maternal complex (SCMC) to fertility, embryogenesis and epigenetic reprogramming

    Scientific Reports 7: Article number: 44667; published online: 20 March 2017; updated: 19 April 2017 The original version of this Article contained an incorrect affiliation list. The correct affiliations are l...

    Sangeetha Mahadevan, Varsha Sathappan, Budi Utama, Isabel Lorenzo… in Scientific Reports (2017)

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  6. Article

    Open Access

    Maternally expressed NLRP2 links the subcortical maternal complex (SCMC) to fertility, embryogenesis and epigenetic reprogramming

    Mammalian parental genomes contribute differently to early embryonic development. Before activation of the zygotic genome, the maternal genome provides all transcripts and proteins required for the transition ...

    Sangeetha Mahadevan, Varsha Sathappan, Budi Utama, Isabel Lorenzo… in Scientific Reports (2017)

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  7. Article

    Docetaxel, 5-fluorouracil, and leucovorin as treatment for advanced gastric cancer: results of a phase II study

    Manuel Constenla, Ramon Garcia-Arroyo, Isabel Lorenzo, Nancy Carrete… in Gastric Cancer (2002)

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