18 Result(s)
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Article
Anti-GD2 synergizes with CD47 blockade to mediate tumor eradication
The disialoganglioside GD2 is overexpressed on several solid tumors, and monoclonal antibodies targeting GD2 have substantially improved outcomes for children with high-risk neuroblastoma. However, approximate...
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Article
Articular cartilage regeneration by activated skeletal stem cells
Osteoarthritis (OA) is a degenerative disease resulting in irreversible, progressive destruction of articular cartilage1. The etiology of OA is complex and involves a variety of factors, including genetic predisp...
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Article
James L. Gowans 1924–2020
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Article
Engagement of MHC class I by the inhibitory receptor LILRB1 suppresses macrophages and is a target of cancer immunotherapy
Exciting progress in the field of cancer immunotherapy has renewed the urgency of the need for basic studies of immunoregulation in both adaptive cell lineages and innate cell lineages. Here we found a central...
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Tumorigenicity as a clinical hurdle for pluripotent stem cell therapies
There is much interest in the applications of pluripotent stem cells for regenerative medicine. In this Perspective, the authors discuss the factors that might contribute to the potential risk of tumorigenicit...
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Article
IL-1β-driven neutrophilia preserves antibacterial defense in the absence of the kinase IKKβ
Pathways dependent on the transcription factor NF-κB provide innate immunity against microbes. Karin and colleagues show that mice lacking the kinase IKKβ have IL-1-dependent neutrophilia. Loss of IL-1 signali...
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Article
Sustained in vitro intestinal epithelial culture within a Wnt-dependent stem cell niche
The development of a long-term intestinal culture system has, until recently, eluded researchers. Here the authors describe a method allowing long-term culture of both small intestine and colon that incorporat...
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Article
Erratum: Depletion of host Langerhans cells before transplantation of donor alloreactive T cells prevents skin graft-versus-host disease
Nat. Med. 10, 510–517 (2004). TCD bone marrow was defined in the article as “T-cell-derived” bone marrow. The correct definition is “T-cell-depleted” bone marrow. We regret the error.
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Article
Depletion of host Langerhans cells before transplantation of donor alloreactive T cells prevents skin graft-versus-host disease
Skin is the most commonly affected organ in graft-versus-host disease (GVHD). To explore the role of Langerhans cells in GVHD, the principal dendritic cells of the skin, we studied the fate of these cells in m...
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Effect of TERT over-expression on the long-term transplantation capacity of hematopoietic stem cells
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Article
Erratum: Langerhans cells renew in the skin throughout life under steady-state conditions
Nature Immunology 3, 1135–1141 In the December 2002 issue of Nature Immunology, incorrect versions of Figures 1f and 4g were supplied. The correct versions of these figures are shown below. This mistake does n...
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Article
Langerhans cells renew in the skin throughout life under steady-state conditions
Langerhans cells (LCs) are bone marrow (BM)–derived epidermal dendritic cells (DCs) that represent a critical immunologic barrier to the external environment, but little is known about their life cycle. Here, ...
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Article
Can stem cells cross lineage boundaries?
Stem cells have traditionally been characterized as either embryonic (pluripotent) or organ-specific. Recent work suggests that the latter can "transdifferentiate" into other cell types, carrying significant i...
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Article
Purified hematopoietic stem cells can differentiate into hepatocytes in vivo
The characterization of hepatic progenitor cells is of great scientific and clinical interest. Here we report that intravenous injection of adult bone marrow cells in the FAH−/− mouse, an animal model of tyrosine...
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Reply to “More or less hematopoietic stem cells”
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Article
The aging of hematopoietic stem cells
We have purified hematopoietic stem cells (HSCs) from the bone marrow of old mice and compared their properties to HSCs in young and middle–aged mice. Single, reconstituting HSCs (by limit dilution) from old a...
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Chapter
Detection of Specific mRNAs by In Situ Hybridization
All glassware should be baked at ⊖ 200°C overnight All solutions, except those containing Tris, should be treated with diethylpyrocarbonate (Sigma, D-5758) for at least 2 hr and then autoclaved. Gloves should ...
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Chapter
The Granzyme A Gene: A Marker for Cytolytic Lymphocytes In Vivo
Granzyme A, initially termed Hanukkah factor (HF) in this laboratory, is a serine protease contained within specialized cytoplasmic granules of activated cytolytic lymphocytes (CTL). These granules contain oth...
