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Article
Platelet-derived growth factor receptor β-targeted positron emission tomography imaging for the noninvasive monitoring of liver fibrosis
Noninvasive quantifying activated hepatic stellate cells (aHSCs) by molecular imaging is helpful for assessing disease progression and therapeutic responses of liver fibrosis. Our purpose is to develop platele...
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Article
Positive rate and quantification of amyloid pathology with [18F]florbetapir in the urban Chinese population
Amyloid deposition is considered the initial pathology in Alzheimer’s disease (AD). Personalized management requires investigation of amyloid pathology and the risk factors for both amyloid pathology and cogni...
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Article
Open AccessPolymer composite microspheres loading 177Lu radionuclide for interventional radioembolization therapy and real-time SPECT imaging of hepatic cancer
Transarterial radioembolization (TARE) with 90Y-labeled glass and resin microspheres is one of the primary treatment strategies for advanced-stage primary and metastatic hepatocellular carcinoma (HCC). However, d...
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Article
Effect of MAO Parameters on the Degradation Property of Medical Mg-6Zn Alloy Prepared by Semisolid Powder Molding
Magnesium alloys are used as bone implants because of their good biocompatibility and degradability. However, due to the rapid and uneven degradation, its clinical application is limited. To improve the corros...
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Article
Open AccessPreclinical evaluation of 68Ga-radiolabeled trimeric affibody for PDGFRβ-targeting PET imaging of hepatocellular carcinoma
Hepatocellular carcinoma (HCC) is a highly vascularized solid carcinoma and tumor vessel–targeted molecular imaging might be effective for early diagnosis of HCC. Herein, we developed a novel trimeric affibody (Z
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Article
Diffusely increased breast uptake of [18F]AlF-NOTA-FAPI-04 related to menstrual status in a patient with papillary thyroid cancer
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Article
Deep regression using 99mTc-DTPA dynamic renal imaging for automatic calculation of the glomerular filtration rate
To develop and evaluate an artificial intelligence (AI) system that can automatically calculate the glomerular filtration rate (GFR) from dynamic renal imaging without manually delineating the regions of inter...
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Article
An automatic fine-grained skeleton segmentation method for whole-body bone scintigraphy using atlas-based registration
Whole-body bone scintigraphy (WBS) is one of the common imaging methods in nuclear medicine. It is a time-consuming, tedious, and error-prone issue for physicians to determine the location of bone lesions whic...
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Article
Open AccessAutomatic differentiation of thyroid scintigram by deep convolutional neural network: a dual center study
99mTc-pertechnetate thyroid scintigraphy is a valid complementary avenue for evaluating thyroid disease in the clinic, the image feature of thyroid scintigram is relatively simple but the interpretation still has...
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Article
Open AccessAutomatic identification of suspicious bone metastatic lesions in bone scintigraphy using convolutional neural network
We aimed to construct an artificial intelligence (AI) guided identification of suspicious bone metastatic lesions from the whole-body bone scintigraphy (WBS) images by convolutional neural networks (CNNs).
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Article
Open AccessRetro-enantio isomer of angiopep-2 assists nanoprobes across the blood-brain barrier for targeted magnetic resonance/fluorescence imaging of glioblastoma
Glioblastoma (GBM), one of the most common primary intracranial malignant tumours, is very difficult to be completely excised by surgery due to its irregular shape. Here, we use an MRI/NIR fluorescence dual-mo...
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Article
Open AccessDeep neural network based artificial intelligence assisted diagnosis of bone scintigraphy for cancer bone metastasis
Bone scintigraphy (BS) is one of the most frequently utilized diagnostic techniques in detecting cancer bone metastasis, and it occupies an enormous workload for nuclear medicine physicians. So, we aimed to ar...
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Article
Anti-prostate cancer activity of 8-hydroxyquinoline-2-carboxaldehyde-thiosemicarbazide copper complexes in vivo by bioluminescence imaging
Copper 8-hydroxyquinoline-2-carboxaldehyde-thiosemicarbazide complex (CuHQTS) is a copper complex with strong anticancer activity against cisplatin-resistant neuroblastoma and prostate cancer cells in vitro by...
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Article
Open AccessQuantification of radioactivity by planar gamma-camera images, a promoted method of absorbed dose in the thyroid after iodine-131 treatment
Iodine-131 (131I) is an essential and widely used radioisotope in thyroid diseases and animal experiments. Planar imaging has been considered the most popular method for 131I thyroid uptake radioactive activity q...
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Article
Cotransfecting norepinephrine transporter and vesicular monoamine transporter 2 genes for increased retention of metaiodobenzylguanidine labeled with iodine 131 in malignant hepatocarcinoma cells
Norepinephrine transporter (NET) transfection leads to significant uptake of iodine-131-labeled metaiodobenzylguanidine (131I-MIBG) in non-neuroendocrine tumors. However, the use of 131I-MIBG is limited by its sh...
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Article
Synthesis and Characterization of Her2-NLP Peptide Conjugates Targeting Circulating Breast Cancer Cells: Cellular Uptake and Localization by Fluorescent Microscopic Imaging
To synthesize a fluorescent Her2-NLP peptide conjugate consisting of Her2/neu targeting peptide and nuclear localization sequence peptide (NLP) and assess its cellular uptake and intracellular localization for...
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Chapter and Conference Paper
Lower Cretaceous Stratigraphy of Eastern Asia: Nonmarine and Marine Correlations
There are abundant nonmarine Cretaceous deposits around the globe, but it is difficult to correlate the nonmarine strata within the international chronostratigraphic framework chart, which was established base...
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Article
2-NBDG Fluorescence Imaging of Hypermetabolic Circulating Tumor Cells in Mouse Xenograft model of Breast Cancer
To determine use of 2-[N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino]-2-deoxy-D-glucose (2-NBDG) as a tracer for detection of hypermetabolic circulating tumor cells (CTC) by fluorescence imaging.
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Article
Upper Jurassic and lower cretaceous of Sanjiang-Middle Amur basin: Non-marine and marine correlation
A comparative analysis of Late Jurassic-Early Cretaceous strata have been done for the Sanjiang-Middle Amur basin, a coal- and oil-bearing area spanning the eastern Heilongjiang of northeastern China and south...
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Article
High-level expression of a functional humanized anti-CTLA4 single-chain variable fragment antibody in Pichia pastoris
The administration of antibodies against the cytotoxic T lymphocyte-associated antigen-4 (CTLA-4) is a promising approach in the upregulation of immune responses in many cancers and infectious diseases. The si...
