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Article
Longitudinal Trajectories of Social Mobility Beliefs among Chinese Adolescents: The Protective Roles of Parental Academic Involvement and Adolescent Future Orientation
Social mobility beliefs play a significant role in sha** adolescents’ adaptive developmental outcomes, including well-being and academic functioning. Nevertheless, existing research may not cast light on the...
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Article
Open AccessScutellarin Alleviates Ovalbumin-Induced Airway Remodeling in Mice and TGF-β-Induced Pro-fibrotic Phenotype in Human Bronchial Epithelial Cells via MAPK and Smad2/3 Signaling Pathways
Asthma is a chronic inflammatory disease characterized by airway hyperresponsiveness (AHR), inflammation, and remodeling. Epithelial-mesenchymal transition (EMT) is an essential player in these alterations. Sc...
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Article
Open AccessDifferences in archaeal diversity and potential ecological functions between saline and hypersaline lakes on Qinghai-Tibet Plateau were driven by multiple environmental and non-environmental factors beyond the salinity
Saline lakes are home to various archaea that play special and crucial roles in the global biogeochemical cycle. The Qinghai-Tibet Plateau hosts a large number of lakes with diverse salinity ranging from 0.1 t...
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Article
Open AccessCritical assessment of variant prioritization methods for rare disease diagnosis within the rare genomes project
A major obstacle faced by families with rare diseases is obtaining a genetic diagnosis. The average "diagnostic odyssey" lasts over five years and causal variants are identified in under 50%, even when capturi...
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Article
Open AccessAssociations between cardiometabolic indices and the risk of diabetic kidney disease in patients with type 2 diabetes
This study was designed to assess the associations between emerging cardiometabolic indices—the atherogenic index of plasma (AIP), the stress hyperglycemia ratio (SHR), the triglyceride-glucose (TyG) index, an...
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Article
Open AccessOptimal HDR exploitation siting of gravity heat pipe geothermal systems via reservoir simulation
Gravity heat pipe system has previously been proven as an environmental and efficient technology in exploiting hot dry rock. However, it is unclear what geothermal reservoir siting is more favorable for the sy...
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Article
Open AccessPredicting the impact of rare variants on RNA splicing in CAGI6
Variants which disrupt splicing are a frequent cause of rare disease that have been under-ascertained clinically. Accurate and efficient methods to predict a variant’s impact on splicing are needed to interpre...
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Article
Open AccessMetagenome-wide analysis uncovers gut microbial signatures and implicates taxon-specific functions in end-stage renal disease
The gut microbiota plays a crucial role in regulating host metabolism and producing uremic toxins in patients with end-stage renal disease (ESRD). Our objective is to advance toward a holistic understanding of...
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Article
Analysis of Causes of Vibration Differences Induced by Different Kinds of Blastholes Based on the Interpretation of Blasting Parameters: A Case Study in Dam Foundation Excavation
The vibration characteristics induced by different kinds of blastholes, such as presplitting blastholes, smooth blastholes, and production blastholes, are quite different. Figuring out the vibration difference...
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Article
Open AccessA multi-omic resource of wheat seed tissues for nutrient deposition and improvement for human health
As a globally important staple crop, wheat seeds provide us with nutrients and proteins. The trend of healthy dietary has become popular recently, emphasizing the consumption of whole-grain wheat products and ...
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Article
In the develo** cerebral cortex: axonogenesis, synapse formation, and synaptic plasticity are regulated by SATB2 target genes
Special AT-rich sequence-binding protein 2 is essential for the development of cerebral cortex and key molecular node for the establishment of proper neural circuitry and function. Mutations in the SATB2 gene lea...
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Article
Robust template feature matching method using motion-constrained DCF designed for visual navigation in asteroid landing
A robust and efficient feature matching method is necessary for visual navigation in asteroid-landing missions. Based on the visual navigation framework and motion characteristics of asteroids, a robust and ef...
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Article
Open AccessCorrection: Motor neuron survival is associated with reduced neuroinflammation and increased autophagy after brachial plexus avulsion injury in aldose reductase-deficient mice
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Article
Open AccessMotor neuron survival is associated with reduced neuroinflammation and increased autophagy after brachial plexus avulsion injury in aldose reductase-deficient mice
Brachial plexus root avulsion (BPRA) is frequently caused by high-energy trauma including traffic accident and birth trauma, which will induces massive motoneurons (MNs) death as well as loss of motor and sens...
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Article
Identification of Pathogenic Variants in RPGRIP1L with Meckel Syndrome and Preimplantation Genetic Testing in a Chinese Family
Meckel syndrome (MKS, OMIM:249000) is a severe multiorgan dysplastic lethal ciliopathy with extreme genetic heterogeneity. Defects in RPGRIP1L are the cause of MKS type 5 (MKS5, OMIM:611561). However, only six di...
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Article
Open AccessDiversity of prokaryotic microorganisms in alkaline saline soil of the Qarhan Salt Lake area in the Qinghai–Tibet Plateau
The composition of microbial communities varies considerably across ecological environments, particularly in extreme environments, where unique microorganisms are typically used as the indicators of environmen...
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Article
Preventing nugget shifting in joining of dissimilar steels via resistance element welding: a numerical simulation
Joining the advanced high-strength steels and conventional steels is a critical issue for the manufacturing of lightweight vehicles. Resistance element welding (REW) is an emerging joining method for dissimila...
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Article
Open AccessAnalysis of atmospheric temperature data by 4D spatial–temporal statistical model
The meteorological data such as temperature of the upper atmosphere is ssential for accurate weather forecasting. The Universal Rawinsonde Observation Program (RAOB) establishes an extensive radiosonde network...
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Article
Electrospinning Janus Nanofibrous Membrane for Unidirectional Liquid Penetration and Its Applications
Janus membrane with opposite wettability on its two sides has witnessed an explosion of interest in the field of liquid spontaneous and directional transport for their promising prospect. The advances in fabric.....
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Article
Intradialytic systolic blood pressure variation can predict long-term mortality in patients on maintenance hemodialysis
It is unclear which time-points of intradialytic blood pressure (BP) best predict prognosis. Thus, it is important to assess the association between different time-points of intradialytic BP and prognosis in c...
