8 Result(s)
within
Hideaki Takata
English
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Article
Open AccessCRISPR imaging reveals chromatin fluctuation at the centromere region related to cellular senescence
The human genome is spatially and temporally organized in the nucleus as chromatin, and the dynamic structure of chromatin is closely related to genome functions. Cellular senescence characterized by an irreve...
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Article
Open AccessHuman metaphase chromosome consists of randomly arranged chromatin fibres with up to 30-nm diameter
During cell division, mitotic chromosomes assemble and are equally distributed into two new daughter cells. The chromosome organisation of the two chromatids is essential for even distribution of genetic mater...
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Article
Open AccessCalcium depletion destabilises kinetochore fibres by the removal of CENP-F from the kinetochore
The attachment of spindle fibres to the kinetochore is an important process that ensures successful completion of the cell division. The Ca2+ concentration increases during the mitotic phase and contributes micro...
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Article
Open AccessCalcium ions function as a booster of chromosome condensation
Chromosome condensation is essential for the faithful transmission of genetic information to daughter cells during cell division. The depletion of chromosome scaffold proteins does not prevent chromosome conde...
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Article
Open AccessChromatin folding and DNA replication inhibition mediated by a highly antitumor-active tetrazolato-bridged dinuclear platinum(II) complex
Chromatin DNA must be read out for various cellular functions and copied for the next cell division. These processes are targets of many anticancer agents. Platinum-based drugs, such as cisplatin, have been us...
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Article
Open AccessChromosome Scaffold is a Double-Stranded Assembly of Scaffold Proteins
Chromosome higher order structure has been an enigma for over a century. The most important structural finding has been the presence of a chromosome scaffold composed of non-histone proteins; so-called scaffol...
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Article
Open AccessThe current shortage and future surplus of doctors: a projection of the future growth of the Japanese medical workforce
Starting in the late 1980s, the Japanese government decreased the number of students accepted into medical school each year in order to reduce healthcare spending. The result of this policy is a serious shorta...
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Protocol
Preparation Methods of Human Metaphase Chromosomes for their Proteome Analysis
Chromosomes are supermolecules that contain most of the DNA within a cell and are visible under optical and electron microscopes. Although they were observed at the earliest stage of genetics, their fundamenta...
