7 Result(s)
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Helena Escuin-Ordinas
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Article
Open AccessPET imaging to non-invasively study immune activation leading to antitumor responses with a 4-1BB agonistic antibody
Molecular imaging with positron emission tomography (PET) may allow the non-invasive study of the pharmacodynamic effects of agonistic monoclonal antibodies (mAb) to 4-1BB (CD137). 4-1BB is a member of the tum...
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Article
Open AccessCombination of pan-RAF and MEK inhibitors in NRAS mutant melanoma
Approximately 20% of melanomas contain a mutation in NRAS. However no direct inhibitor of NRAS is available. One of the main signaling pathways downstream of NRAS is the MAPK pathway. In this study we investig...
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Open AccessInnate resistance of PD-1 blockade through loss of function mutations in JAK resulting in inability to express PD-L1 upon interferon exposure
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Open AccessDetection of antibody therapy-induced anti-tumor immune responses using anti-CD8 immuno-pet
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Open AccessCutaneous wound healing through paradoxical MAPK activation by BRAF inhibitors
BRAF inhibitors are highly effective therapies for the treatment of BRAFV600-mutated melanoma, with the main toxicity being a variety of hyperproliferative skin conditions due to paradoxical activation of the mit...
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Article
Open AccessPotentiating adoptive cell therapy using synthetic IL-9 receptors
Synthetic receptor signalling has the potential to endow adoptively transferred T cells with new functions that overcome major barriers in the treatment of solid tumours, including the need for conditioning ch...
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Open AccessPublisher Correction: Potentiating adoptive cell therapy using synthetic IL-9 receptors
