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Article
A CD3-bispecific molecule targeting P-cadherin demonstrates T cell-mediated regression of established solid tumors in mice
Strong evidence exists supporting the important role T cells play in the immune response against tumors. Still, the ability to initiate tumor-specific immune responses remains a challenge. Recent clinical tria...
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Article
Open AccessPET imaging to non-invasively study immune activation leading to antitumor responses with a 4-1BB agonistic antibody
Molecular imaging with positron emission tomography (PET) may allow the non-invasive study of the pharmacodynamic effects of agonistic monoclonal antibodies (mAb) to 4-1BB (CD137). 4-1BB is a member of the tum...
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Article
Noninvasive Positive Pressure Ventilation for Acute Respiratory Failure in Delirious Patients: Understudied, Underreported, or Underappreciated? A Systematic Review and Meta-analysis
We performed a systematic review and meta-analysis of the literature to determine the prevalence of delirium in patients receiving noninvasive positive pressure ventilation (NPPV) for acute respiratory failure...
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Article
Open AccessQuantification of lung surface area using computed tomography
To refine the CT prediction of emphysema by comparing histology and CT for specific regions of lung. To incorporate both regional lung density measured by CT and cluster analysis of low attenuation areas for c...
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Article
Open AccessAn unusual exacerbation of chronic obstructive pulmonary disease (COPD) with herpes simplex tracheitis: case report
Chronic obstructive pulmonary disease (COPD) is a common cause of morbidity in the UK and is increasingly seen in elderly patients, often requiring multiple courses of steroids. We present a case of a 72 year ...
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Article
Daytime variability in carotid baroreflex function in healthy human subjects
Variability of blood pressure is limited by arterial baroreceptors, yet blood pressure still shows circadian changes. This study was undertaken to examine if the responses to the carotid baroreflex also change...
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Article
Co-morbidity and acute decompensations of COPD requiring non-invasive positive-pressure ventilation
To assess the prevalence and the impact of chronic and/or acute non-respiratory co-morbidity on short and longer-term outcome of non-invasive positive pressure ventilation (NIPPV) in acute decompensations of c...
