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Article
Open AccessVE-Cadherin modulates β-catenin/TCF-4 to enhance Vasculogenic Mimicry
Vasculogenic Mimicry (VM) refers to the capacity to form a blood network from aggressive cancer cells in an independent way of endothelial cells, to provide nutrients and oxygen leading to enhanced microenviro...
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Protocol
Co-immunoprecipitation of Protein Complexes from Different Subcellular Compartments in Vasculogenic Mimicry Studies
Aberrant extravascular expression of has been observed in associated with ; we have recently shown that in VM prone cells (mainly in the form of phospho-VE-cadherin in Y658) is in part located in the c...
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Article
VE-cadherin promotes vasculogenic mimicry by modulating kaiso-dependent gene expression
Aberrant extra-vascular expression of VE-cadherin (VEC) has been observed in metastasis associated with vasculogenic mimicry (VM); however, the ultimate reason why non-endothelial VEC favors the acquisition of...
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Article
Open AccessPIM kinases mediate resistance of glioblastoma cells to TRAIL by a p62/SQSTM1-dependent mechanism
Glioblastoma (GBM) is the most common and aggressive brain tumor and is associated with poor prognosis. GBM cells are frequently resistant to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and...
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Article
Open AccessAutophagy requires poly(adp-ribosyl)ation-dependent AMPK nuclear export
AMPK is a central energy sensor linking extracellular milieu fluctuations with the autophagic machinery. In the current study we uncover that Poly(ADP-ribosyl)ation (PARylation), a post-translational modificat...
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Article
Open AccessInnate resistance of PD-1 blockade through loss of function mutations in JAK resulting in inability to express PD-L1 upon interferon exposure
