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  1. No Access

    Article

    Mutational landscape influences immunotherapy outcomes among patients with non-small-cell lung cancer with human leukocyte antigen supertype B44

    Human leukocyte antigen (HLA)-B has been recognized as a major determinant of discrepancies in disease outcomes, and recent evidence indicates a role in immune checkpoint blockade (ICB) efficacy. The B44 super...

    Amy L. Cummings, Jaklin Gukasyan, Henry Y. Lu, Tristan Grogan… in Nature Cancer (2020)

  2. Article

    Open Access

    ATR inhibition facilitates targeting of leukemia dependence on convergent nucleotide biosynthetic pathways

    Leukemia cells rely on two nucleotide biosynthetic pathways, de novo and salvage, to produce dNTPs for DNA replication. Here, using metabolomic, proteomic, and phosphoproteomic approaches, we show that inhibit...

    Thuc M. Le, Soumya Poddar, Joseph R. Capri, Evan R. Abt… in Nature Communications (2017)

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  3. Article

    Open Access

    Innate resistance of PD-1 blockade through loss of function mutations in JAK resulting in inability to express PD-L1 upon interferon exposure

    Daniel Shin, Angel Garcia-Diaz, Jesse Zaretsky… in Journal for ImmunoTherapy of Cancer (2015)

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