4 Result(s)

Article

Innate resistance of PD-1 blockade through loss of function mutations in JAK resulting in inability to express PD-L1 upon interferon exposure

Daniel Shin, Angel Garcia-Diaz, Jesse Zaretsky… in Journal for ImmunoTherapy of Cancer (2015)

Article

Detection of antibody therapy-induced anti-tumor immune responses using anti-CD8 immuno-pet

Richard Tavare, Helena Escuin-Ordinas… in Journal for ImmunoTherapy of Cancer (2015)

Article

Combination of pan-RAF and MEK inhibitors in NRAS mutant melanoma

Approximately 20% of melanomas contain a mutation in NRAS. However no direct inhibitor of NRAS is available. One of the main signaling pathways downstream of NRAS is the MAPK pathway. In this study we investig...

Mohammad Atefi, Bjoern Titz, Earl Avramis, Charles Ng, Deborah JL Wong… in Molecular Cancer (2015)

Article

PET imaging to non-invasively study immune activation leading to antitumor responses with a 4-1BB agonistic antibody

Molecular imaging with positron emission tomography (PET) may allow the non-invasive study of the pharmacodynamic effects of agonistic monoclonal antibodies (mAb) to 4-1BB (CD137). 4-1BB is a member of the tum...

Helena Escuin-Ordinas, Mark W Elliott… in Journal for ImmunoTherapy of Cancer (2013)