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Article
Open AccessResilient, environment tolerant and biocompatible electroluminescent devices with enhanced luminance based on compliant and self-adhesive electrodes
Electroluminescent (EL) devices are of great significance for expanding the application range of optoelectronics. However, the realization of EL devices with environment-tolerance, stretchability, mechanical c...
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Article
Analysis and Modeling of Intermittent Fluctuation Mechanisms of Piezoelectric Impact-Induced Vibration Cantilever Energy Harvester
Piezoelectric impact-induced vibration cantilever energy harvesters for conventional energy have low ambient vibration frequencies. Expanding the response bandwidth of vibratory energy harvesters and improving...
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Article
Map** the technological trajectory of inorganic nanomaterials in the cancer field
Cancer remains one of the primary factors leading to premature death in humans. Conventional therapeutic approaches result in significant harm to normal tissue cells and impede the effective treatment of cance...
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Article
TRIM21/USP15 balances ACSL4 stability and the imatinib resistance of gastrointestinal stromal tumors
Imatinib has become an exceptionally effective targeted drug for treating gastrointestinal stromal tumors (GISTs). Despite its efficacy, the resistance to imatinib is common in GIST patients, posing a signific...
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Article
Deubiquitylation of Rab35 by USP32 promotes the transmission of imatinib resistance by enhancing exosome secretion in gastrointestinal stromal tumours
Imatinib is a tyrosine kinase inhibitor that is widely used to combat gastrointestinal stromal tumours (GISTs). However, secondary resistance to imatinib is an important challenge in GIST treatment. Recent stu...
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Article
N6-methyladenosine-modified USP13 induces pro-survival autophagy and imatinib resistance via regulating the stabilization of autophagy-related protein 5 in gastrointestinal stromal tumors
Secondary resistance to imatinib (IM) represents a major challenge for therapy of gastrointestinal stromal tumors (GISTs). Aberrations in oncogenic pathways, including autophagy, correlate with IM resistance. ...
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Article
Evaluation of prostate health index in predicting bone metastasis of prostate cancer before bone scanning
In patients undergoing bone scanning, the positive rate of bone metastasis (BM) of prostate cancer (PCa) is quite low. The main purpose of this study was to explore the application of %p2PSA and prostate healt...
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Article
Open AccessImproving CoQ10 productivity by strengthening glucose transmembrane of Rhodobacter sphaeroides
Several Rhodobacter sphaeroides have been widely applied in commercial CoQ10 production, but they have poor glucose use. Strategies for enhancing glucose use have been widely exploited in R. sphaeroides. Neverthe...
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Article
Sample Fidelity of Formation Sampling While Drillings
Formation sampling while drilling (FSWD) technology has become a research hotspot in oilfield development at home and abroad. The technology is characterized by a comparatively short operation time. Since the ...
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Article
Open AccessBlockade of checkpoint receptor PVRIG unleashes anti-tumor immunity of NK cells in murine and human solid tumors
Although checkpoint-based immunotherapy has shown exciting results in the treatment of tumors, around 70% of patients have experienced unresponsiveness. PVRIG is a recently identified immune checkpoint recepto...
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Article
Open AccessSingle-cell analysis reveals the origins and intrahepatic development of liver-resident IFN-γ-producing γδ T cells
γδ T cells are heterogeneous lymphocytes located in various tissues. However, a systematic and comprehensive understanding of the origins of γδ T cell heterogeneity and the extrathymic developmental pathway as...
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Article
Open AccessSerum inflammatory factors are positively correlated with the production of specific antibodies in coronavirus disease 2019 patients
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Article
Design and preparation of integrated voltage divider for silicon drift detector by ion implantation
An integrated voltage divider, providing a transverse electric field, plays an important role in silicon drift detector (SDD). In this paper, an curve-style voltage divider is proposed and two dimensional nume...
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Article
Tissue-resident lymphocytes: from adaptive to innate immunity
Efficient immune responses against invading pathogens often involve coordination between cells from both the innate and adaptive immune systems. For multiple decades, it has been believed that CD8+ memory T cells...
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Article
Natural killer cells in liver diseases
The liver has been characterized as a frontline lymphoid organ with complex immunological features such as liver immunity and liver tolerance. Liver tolerance plays an important role in liver diseases includin...
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Chapter
Erratum to: Immnopathology
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Chapter
The Innate Immunity
Innate immunity refers to the naturally formed innate immune defensive functions through evolution, which makes up the first line of defense against microbial pathogens. Innate immune system is the natural imm...
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Article
Expanded polystyrene foams containing ammonium polyphosphate and nano-zirconia with improved flame retardancy and mechanical properties
Expanded polystyrene (EPS) foams were flame retarded using ammonium polyphosphate (APP) and nano-zirconia (nano-ZrO2) by means of phenolic resin as a binder. It is found that the incorporation of a small amount (...
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Chapter
Immunotolerance and Immunoregulation
The immune system clears pathogens and microorganisms by responding to antigen stimulation under normal circumstances; this is often referred to as the positive immune response. In contrast, the immune system ...
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Chapter
Components of the Immune System
Immune system is mainly composed of immune organs, tissues, cells, and molecules, all of which interact with each other to perform immune functions. Immune tissues may also be referred to as the lymphoid tissu...
