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Map** the technological trajectory of inorganic nanomaterials in the cancer field

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Abstract

Cancer remains one of the primary factors leading to premature death in humans. Conventional therapeutic approaches result in significant harm to normal tissue cells and impede the effective treatment of cancer. In recent years, the benefits of inorganic nanomaterials in cancer research have become increasingly evident, and they are expected to provide new ideas for diagnosing and treating cancer. This study aims to reveal the technological trajectory and important applications of inorganic nanomaterials in cancer diagnosis and treatment better to understand their technological development trends and technical priorities. A patent citation network was constructed to find the milestone patents of inorganic nanomaterials in the field of cancer by main path–derived path analysis, and a citation analysis method based on the PageRank (PR) algorithm was used to identify the high PR value patents of inorganic nanotechnology in cancer. The study found that the overall technological development trajectory of inorganic nanomaterials in cancer is linear, with a focus on enhancing technical aspects such as biological detection and imaging, drug delivery, phototherapy, magnetic hyperthermia, and radiotherapy, progressively enhancing the diagnostic and therapeutic effects, and realizing the integration of diagnosis and treatment. Gold nanomaterials are essential in cancer diagnosis and treatment. Carbon-based nanomaterials, magnetic nanomaterials, upconversion luminescent materials, copper-based nanoparticles, quantum dots, and other inorganic nanomaterials will become significant R&D directions.

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Funding

This study was supported by the Shanghai Center for Drug Evaluation and Inspection under the project “Control Strategy and Regulatory Consideration of Pharmaceutical and Pharmaceutical Combination Products Based on Patent Technology Trajectory” (No. 2222430097).

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  1. School of Business Administration, Shenyang Pharmaceutical University, Shenyang, China

    Donglin Wei, Haoyu Sun, Min Zhang, Yingying Zhao & Hongmei Yuan

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  1. Donglin Wei
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  2. Haoyu Sun
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  3. Min Zhang
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Contributions

Donglin Wei: investigation, methodology, visualization, writing—original draft. Haoyu Sun: writing (review and editing), methodology, visualization. Min Zhang: data curation. Yingying Zhao: investigation. Hongmei Yuan: supervision, project administration, funding acquisition, writing—review and editing.

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Correspondence to Hongmei Yuan.

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Appendix

Appendix

Search formula: TIAB = ((“inorganic” OR “AuNPs” OR “Silica” OR “SiNPs” OR “iron oxide” OR “IONPs” OR “QDs” OR “Magnetic” OR “metal–organic frameworks” OR “MOF” OR “metallic” OR “metal-based” OR “carbon*” OR “CNTs” OR “Gold” OR “metal based carriers” OR “quantum dot” OR “MSNs” OR “SPION” OR “titanium dioxide” OR “Fullerene” OR “calcium phosphate” OR “CaPNPs” OR “Ag” OR “AGulX” OR “Gd” OR “HfO2” OR “IONPs” OR “Black phosphorus” OR “BP” OR “CPNs” OR “LDHs” OR “layered double hydroxides” OR “manganese dioxide” OR “MnO2” OR “Graphene” OR “Copper*” OR “Up*conversion” OR “UCNs” OR “Au” OR “Pd” OR “Transition metal oxide” OR “Two dimensional” OR “silver” OR “zirconium oxide” OR “nanodiamonds” OR “Carbon dots” OR “CDs” OR “Nano*diamond*”) AND (“nano*”)) AND (“tumor” OR “cancer”).

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Wei, D., Sun, H., Zhang, M. et al. Map** the technological trajectory of inorganic nanomaterials in the cancer field. J Nanopart Res 26, 66 (2024). https://doi.org/10.1007/s11051-024-05975-8

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  • DOI: https://doi.org/10.1007/s11051-024-05975-8

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