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Article
Open AccessSingle cell transcriptomic analysis of human amnion identifies cell-specific signatures associated with membrane rupture and parturition
The human amnion is an intrauterine tissue which is involved in the initiation of parturition. In-depth understanding of gene expression signatures of individual cell types in the amnion with respect to membra...
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Article
Open AccessDihydroartemisinin selectively inhibits PDGFRα-positive ovarian cancer growth and metastasis through inducing degradation of PDGFRα protein
To develop traditional medicines as modern pharmacotherapies, understanding their molecular mechanisms of action can be very helpful. We have recently reported that Artemisinin and its derivatives, which are c...
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Article
RIP1 kinase activity-dependent roles in embryonic development of Fadd-deficient mice
RIP1 is an essential regulator of TNF-induced signaling complexes mediating NF-κB activation, apoptosis and necroptosis. Loss of Rip1 rescues the embryonic lethality of Fadd or Caspase-8-deficient mice, even thou...
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Article
Open AccessmicroRNA and thyroid hormone signaling in cardiac and skeletal muscle
Thyroid hormone (TH) signaling plays critical roles in the differentiation, growth, metabolism, and physiological function of all organs or tissues, including heart and skeletal muscle. Due to the significant ...
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Article
Open AccessRegulation of fatty acid composition and lipid storage by thyroid hormone in mouse liver
Thyroid hormones (THs) are potent hormones modulating liver lipid homeostasis. The perturbation of lipid homeostasis is a hallmark of non-alcoholic fatty liver disease (NAFLD), a very common liver disorder. It...
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Article
Open AccessRecent progress in the study of brown adipose tissue
Brown adipose tissue in mammals plays a critical role in maintaining energy balance by thermogenesis, which means dissipating energy in the form of heat. It is held that in mammals, long-term surplus food inta...
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Article
Thyroid hormone action in metabolic regulation
Thyroid hormone plays pivotal roles in growth, differentiation, development and metabolic homeostasis via thyroid hormone receptors (TRs) by controlling the expression of TR target genes. The transcriptional a...
