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Article
In the develo** cerebral cortex: axonogenesis, synapse formation, and synaptic plasticity are regulated by SATB2 target genes
Special AT-rich sequence-binding protein 2 is essential for the development of cerebral cortex and key molecular node for the establishment of proper neural circuitry and function. Mutations in the SATB2 gene lea...
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Extension of the Lifespan of a Mouse Model of Rett Syndrome by Intracerebroventricular Delivery of MECP2
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Article
Open AccessLoss of CREST leads to neuroinflammatory responses and ALS-like motor defects in mice
Amyotrophic lateral sclerosis (ALS) is a late onset neurodegenerative disease with fast progression. ALS has heavy genetic components in which a series of genetic mutations have been identified. In 2013, Mutat...
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Article
Open AccessThe autism-related gene SNRPN regulates cortical and spine development via controlling nuclear receptor Nr4a1
The small nuclear ribonucleoprotein polypeptide N (SNRPN) gene, encoding the RNA-associated SmN protein, duplications or deletions of which are strongly associated with neurodevelopmental disabilities. SNRPN-codi...
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Article
Open AccessRecent progress in the study of brown adipose tissue
Brown adipose tissue in mammals plays a critical role in maintaining energy balance by thermogenesis, which means dissipating energy in the form of heat. It is held that in mammals, long-term surplus food inta...
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Article
Repression of interferon-γ expression in T cells by Prospero-related Homeobox protein
Interferon-gamma (IFN-γ) is a major proinflammatory effector and regulatory cytokine produced by activated T cells and NK cells. IFN-γ has been shown to play pivotal roles in fundamental immunological processe...
