23 Result(s)

Article

Neuroendokrine Neoplasien der Appendix und des Kolorektums

Die adäquate Diagnose und Therapie der neuroendokrinen Neoplasien der Appendix und des Kolorektums setzen eine genaue Kenntnis ihrer Klassifikation nach WHO und TNM voraus. Die neue WHO-Klassifizierung untersc...

Prof. Dr. G. Klöppel, H. Scherübl in Der Pathologe (2011)

Article

Neuroendokrine Tumoren des Magens

Diagnose und Therapie der neuroendokrinen Tumoren (NET) des Magens basieren auf ihrer sicheren Klassifikation und Risikostratifizierung. Da zudem die NET des Magens in den letzten 35 Jahren deutlich an Häufigk...

Prof. Dr. G. Klöppel, H. Scherübl in Der Pathologe (2010)

Article

A novel tetracycline-controlled transactivator–transrepressor system enables external control of oncolytic adenovirus replication

The use of restricted replication-competent adenoviruses (RRCAs) inducing tumor cell-specific lysis is a promising approach in cancer gene therapy. However, the use of RRCAs in humans carries considerable risk...

H Fechner, X Wang, M Srour, U Siemetzki, H Seltmann, A P Sutter, H Scherübl… in Gene Therapy (2003)

Article

A pilot study of irinotecan (CPT-11) as single-agent therapy in patients with locally advanced or metastatic esophageal carcinoma

This study assessed the efficacy and safety of irinotecan (CPT-11) in the treatment of patients with unresectable esophageal carcinoma.

F. Mühr-Wilkenshoff, W. Hinkelbein… in International Journal of Colorectal Disease (2003)

Article

Hypericin activated by an incoherent light source has photodynamic effects on esophageal cancer cells

Abstract

M. Höpfner, K. Maaser, A. Theiss, M. Lenz… in International Journal of Colorectal Disease (2003)

Article

Screening for oesophageal neoplasia in patients with head and neck cancer

Due to advanced disease at the time of diagnosis the prognosis of oesophageal cancer is generally poor. As mass screening for oesophageal cancer is neither feasible nor reasonable, high-risk groups should be i...

H Scherübl, B von Lampe, S Faiss, P Däubler, P Bohlmann… in British Journal of Cancer (2002)

Article

Growth inhibition and apoptosis induced by P2Y₂ receptors in human colorectal carcinoma cells: involvement of intracellular calcium and cyclic adenosine monophosphate

Extracellular nucleotides induce apoptosis and inhibit growth of colorectal cancer cells. To understand the underlying signaling pathways, we investigated the role of nucleotide-sensitive P2 receptors and foc...

M. Höpfner, K. Maaser, B. Barthel… in International Journal of Colorectal Disease (2001)

Article

GABA_C receptors in neuroendocrine gut cells: a new GABA-binding site in the gut

Although GABA_C receptors play a crucial role in the mammalian central nervous system, their functional expression in peripheral tissues has not yet been studied. Using the gut neuroendocrine tumor cell line STC-...

A. Jansen, M. Hoepfner, K.-H. Herzig, E.-O. Riecken, H. Scherübl in Pflügers Archiv (2000)

Article

Trans-complementation of vector replication versus Coxsackie-adenovirus-receptor overexpression to improve transgene expression in poorly permissive cancer cells

Gene therapy of cancer requires high-level expression of therapeutic transgenes in the target cells. Poor gene transfer is an important limitation to adenovector-mediated cancer gene therapy. We investigated t...

H Fechner, X Wang, H Wang, A Jansen, M Pauschinger, H Scherübl… in Gene Therapy (2000)

Article

A 7-year-old child with primary tumour localisation in the distal duodenum – new imaging procedures for an improved diagnosis

Duodenal gastrinomas in childhood are extremely rare and often missed at first medical consultation. We report on a 7-year-old child with sporadic gastrinoma of primary localisation in the distal duodenum. Sma...

D. Cholewa, J. Waldschmidt, K. Hoffmann, M. Bäder… in European Journal of Pediatrics (1997)

Chapter and Conference Paper

Drug Therapy in Metastatic Neuroendocrine Tumors of the Gastroenteropancreatic System

Successful treatment of neuroendocrine tumor disease of the gastroenteropancreatic system requires a multimodal approach. Radical tumor surgery is required before other therapies are initiated. So far, only su...

S. Faiss, H. Scherübl, E. O. Riecken… in New Perspectives in Molecular and Clinical… (1996)

Chapter and Conference Paper

Molekular- und zellbiologische Aspekte neuroendokriner Tumorerkrankungen des gastroenteropankreatischen Systems

Neurone und neuroendokrine Zellen haben eine Vielzahl von Merkmalen gemeinsam. Der Einsatz molekular- und zellbiologischer Verfahren hat das Verständnis physiologischer und pathophysiologischer Vorgänge wie Wa...

B. Wiedenmann, H. Scherübl, M. John… in Molekularbiologische Grundlagen der Gastro… (1995)

Article

Intestinal intraepithelial T cell derived lymphoma not associated with enteropathy

T. Schneider, R. Ullrich, H. Scherübl, A. Schmitt-Gräff… in The clinical investigator (1994)

Article

Different β-subunits determine G-protein interaction with transmembrane receptors

REGULATORY GTP-binding proteins (G proteins) are membrane-attached heterotrimers (α, β, γ) that mediate cellular responses to a wide variety of extracellular stimuli^1,2. They undergo a cycle of guanine-nucleotide...

C. Kleuss, H. Scherübl, J. Hescheler, G. Schultz, B. Wittig in Nature (1992)