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Open AccessAbstracts from the 4th ImmunoTherapy of Cancer Conference
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Experimental simulation of dissimilar weld metal of high manganese steels by arc melting technique
This paper presents an arc melting technique that allows simulating dissimilar weld metal of high manganese steels with ferritic and martensitic steel grades. The objective of this initial study was to conceiv...
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Open AccessImmune response of healthy horses to DNA constructs formulated with a cationic lipid transfection reagent
Deoxyribonucleic acid (DNA) vaccines are used for experimental immunotherapy of equine melanoma. The injection of complexed linear DNA encoding interleukin (IL)-12/IL-18 induced partial tumour remission in a c...
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Chronisch entzündliche Darmerkrankungen
Pathogenese und Therapie der chronisch entzündlichen Darmerkrankungen sind gekennzeichnet durch eine auffällige Diskrepanz. Einerseits besteht weitgehend Übereinkunft, dass die Pathogenese wesentlich auf einer...
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Radioimmuntherapie
Die Verwendung von monoklonalen Antikörpern als Träger für zytotoxische Reagenzien ist ein Konzept zur Verbesserung der Tumorbehandlung, das bereits Anfang des vorigen Jahrhunderts für Antiseren benutzt wurde.
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Zellinvasion und Metastasierung
Als Metastasierung wird der Prozess der Absiedlung und des Wachstums von Tumorzellen in einem vom Primärtumor entfernten Organ bezeichnet. Da der heutige Stand der medizinischen Technik die Entfernung nahezu j...
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The gut as an organ of immunology
Abstract
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Increased expression of interleukin-12 receptor β2 on lamina propria mononuclear cells of patients with active Crohn's disease
Abstract
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The in vitro anti-inflammatory effects of recombinant anti-CD25 immunotoxin on lamina propria T cells of patients with inflammatory bowel disease are not sufficient to cure experimental colitis in mice
Background and aims: In chronic inflammatory bowel disease (IBD) such as Crohn's disease and ulcerative colitis an aberrant mucosal immune regulation is observed accompanied by upregulation of pr...
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Proliferation-dependent induction of apoptosis by the retinoid CD437 in p53-mutated keratinocytes
6-[3-(1-adamantyl)-4-hydroxyphenyl]-2-Naphthalene carboxylic acid (CD437) is a synthetic retinoid with strong apoptogenic properties in various neoplastic cell lines. CD437 was shown to induce apoptosis in ma...
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Transfection of dendritic cells (DCs) with the CIITA gene: increase in immunostimulatory activity of DCs
Dendritic cells (DCs) are the major antigen-presenting cells. They are able to present tumor antigens to immunologic effector cells. MHC class II molecules on DC surfaces play an important role in priming effe...
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Ballistic transfer of minimalistic immunologically defined expression constructs for IL4 and CTLA4 into the corneal epithelium in mice after orthotopic corneal allograft transplantation
Background: Experiments were performed to determine whether corneal epithelium transfected with minimalistic immunologically defined expression constructs for the extracellular fragment of CTLA4 and for interleu...
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Open AccessPhase I clinical study applying autologous immunological effector cells transfected with the interleukin-2 gene in patients with metastatic renal cancer, colorectal cancer and lymphoma
Natural killer-like T lymphocytes termed cytokine-induced killer (CIK) cells have been shown to eradicate established tumours in a severe combined immune deficient (SCID) mouse/human lymphoma model. Recently, ...
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Regulation and possible function of axl expression in immature human mast cells
The receptor tyrosine kinase Axl which expresses extracellular domains reminiscent of cell adhesion molecules, is involved in homotypic binding as well as in intracellular signaling of myeloid progenitor cells. ...
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Vaccination with IL-7 gene-modified autologous melanoma cells can enhance the anti-melanoma lytic activity in peripheral blood of patients with a good clinical performance status: a clinical phase I study
Recently, cytokine gene transfer into tumour cells has been shown to mediate tumour regression in animal models via immunomodulation. Consequently, a number of clinical protocols have been developed to treat c...
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Vaccination with IL-12 gene-modified autologous melanoma cells: preclinical results and a first clinical phase I study
Cytokine gene transfer into tumor cells has been shown to mediate tumor regression and antimetastatic effects in several animal models via immunomodulation. Therefore, clinical protocols have been developed to...
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Functional Involvement of CD44, a Family of Cell Adhesion Molecules, in Immune Responses, Tumour Progression and Haematopoiesis
Cell-cell and cell-extracellular matrix (ECM) interactions play fundamental roles in many biological processes. Cells adhere to the ECM and to each other via specific cell surface receptors such as the selecti...
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Inhibition of G Proteins by Antisense Drugs
In a multicellular organism, cells communicate with each other mostly through the cell surface, which is represented by the plasma membrane with its lipids and proteins. A subset of the membrane proteins, i.e....
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Increase of proliferation rate and enhancement of antitumor cytotoxicity of expanded human CD3+CD56+ immunologic effector cells by receptor-mediated transfection with the interleukin-7 gene
Cytokine-induced killer (CIK) cells have been shown to eradicate established tumors in a SCID mouse–human lymphoma model. CIK cells depend on exogenous addition of cytokines such as interleukin-2 (IL-2), inter...
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Immuntherapie
Immuntherapeutische Verfahren bei Patienten mit malignen Tumoren können in aktive und passive Ansätze unterteilt werden. Unter aktiver Immuntherapie versteht man den Versuch, das Immunsystem des Patienten unsp...
