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Article
Open AccessCav2.3 R-type calcium channels: from its discovery to pathogenic de novo CACNA1E variants: a historical perspective
So-called pharmacoresistant (R-type) voltage-gated Ca2+ channels are structurally only partially characterized. Most of them are encoded by the CACNA1E gene and are expressed as different Cav2.3 splice variants (...
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Article
Open AccessMedium-chain fatty acids modulate myocardial function via a cardiac odorant receptor
Several studies have demonstrated the expression of odorant receptors (OR) in various human tissues and their involvement in different physiological and pathophysiological processes. However, the functional ro...
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Article
Open AccessNeuronal developmental gene and miRNA signatures induced by histone deacetylase inhibitors in human embryonic stem cells
Human embryonic stem cells (hESCs) may be applied to develop human-relevant sensitive in vitro test systems for monitoring developmental toxicants. The aim of this study was to identify potential developmental to...
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Article
Erratum to: CaV2.3 E-/R-type voltage-gated calcium channels modulate sleep in mice
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Article
Open AccessFam40b is required for lineage commitment of murine embryonic stem cells
FAM40B (STRIP2) is a member of the striatin-interacting phosphatase and kinase (STRIPAK) complex that is involved in the regulation of various processes such as cell proliferation and differentiation. Its role...
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Article
Cav2.3 E-/R-type voltage-gated calcium channels modulate sleep in mice
Mammalian sleep is characterized by cycles of REM and non-REM (NREM), i.e. slow-wave sleep (SWS) phases. The major neuroanatomical basis of SWS is the thalamocortical circuitry, which operates in different fun...
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Article
Engineered embryonic stem cells for regnerative nedicine
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Article
Kalziumkanalopathien des Menschen
Spannungsgesteuerte Ca2+-Kanäle spielen eine Schlüsselrolle bei einer Vielzahl physiologischer Prozesse. Innerhalb des letzten Jahrzehnts hat die Zahl der als sog. Ca2+-Kanalopathien definierten Krankheitsentität...
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Article
The SRC family kinase LYN redirects B cell receptor signaling in human SLP65-deficient B cell lymphoma cells
SLP65 represents a critical component in (pre-) B cell receptor signal transduction but is compromised in a subset of pre-B cell-derived acute lymphoblastic leukemia. Based on these findings, we investigated (...
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Chapter
Antiarrhythmika
Das Herz ist ein Netzwerk elektrisch gekoppelter Muskelzellen, das eine wellenartige Ausbreitung von elektrischen Potentialen, den Aktionspotentialen, ermöglicht. Ausgehend vom primären Schrittmacherzentrum, d...
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Article
Outwards currents in embryonic stem cell-derived cardiomyocytes
The aim of the present study was to investigate the expression and functional role of outwards currents during the early stages of cardiomyogenesis. The predominant repolarizing current in early-stage, embryon...
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Article
35th Annual Meeting of the European Association for the Study of Diabetes
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Article
Open AccessIncreased doxorubicin uptake and toxicity in multicellular tumour spheroids treated with DC electrical fields
Electrochemotherapy (ECT) is a new approach to the treatment of tumours. In the present study, multicellular prostate tumour spheroids were treated with non-lethal direct current (DC) electrical fields, and up...
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Article
Action potential propagation failures in long-term recordings from embryonic stem cell-derived cardiomyocytes in tissue culture
Three-dimensional cell aggregates (embryoid bodies, EBs) containing clusters of spontaneously beating cardiomyocytes were derived from permanent mouse embryonic stem (ES) cells. Extracellular recordings of th...
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Chapter
Antiarrhythmika
Das Herz ist ein Netzwerk elektrisch gekoppelter Muskelzellen, das eine wellenartige Ausbreitung von elektrischen Potentialen, den Aktionspotentialen, ermöglicht. Ausgehend vom primären Schrittmacherzentrum, d...
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Article
DC electrical field-induced c-fos expression and growth stimulation in multicellular prostate cancer spheroids
The effects of electrical direct current (DC) field pulses on c-fos expression, growth kinetics and vitality patterns of multicellular tumour spheroids (MCSs) were studied. Monitoring the membrane potential of...
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Article
The isoquinoline derivative LOE 908 selectively blocks vasopressin-activated nonselective cation currents in A7r5 aortic smooth muscle cells
The effect of (R,S)-(3,4-dihydro6,7-dimethoxyisoquinoline-1-yl)-2-phenyl-N,N-di- [2- (2, 3,4-trimethoxyphenyl)ethyl]-acetamide (LOE 908), a cation channel blocker in HL-60 promyeloblasts, was studied in the A7r5 ...
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Chapter and Conference Paper
Embryonic Stem Cell Derived Cardiogenesis and Myogenesis
Permanent cell lines of embryonic stem (ES) cells established from totipotent cells of the mouse embryo provide one of the most important cellular systems for developmental biologists. ES cells offer a suitabl...
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Chapter and Conference Paper
Aus pluripotenten embryonalen Stammzellen differenzierte Herzmuskelzellen als in vitro-System für pharmakologische und embryotoxikologische Studien
Pluripotente embryonale Stammzellen (ESC) der Maus sind permanente Linien aus der inneren Zellmasse von Blastozysten oder einzelnen Blastomeren von 8-Zell-Embryonen. Sie differenzieren nach Kultivierung in Zel...
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Chapter
Nonselective Cation Channels: Physiological and Pharmacological Modulations of Channel Activity
Cation channels play a major role in fast and sustained cellular responses to hormones and neurotransmitters. They contribute to depolarization of the membrane and — in most cases -to an increase in the intrac...
