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Article
Andrologische Anamnese – welche Fragen sollten auch Gynäkologen stellen?
Eine andrologische Abklärung ist sinnvoll, wenn trotz regelmäßigen ungeschützten Geschlechtsverkehrs nach 12 Monaten keine Schwangerschaft eingetreten ist. Eine andrologische Diagnostik vor Ablauf der 12 Monat...
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Article
Fertilität bei Patienten mit einem Klinefelter-Syndrom (47,XXY)
Während der letzten 10 Jahre hat sich das Wissen um die Fertilitätschancen von Patienten mit einem Klinefelter-Syndrom (KS, 47,XXY) erheblich verändert, insbesondere auch vor dem Hintergrund der Möglichkeiten ...
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Article
ISA, ISSAM, EAU, EAA and ASA recommendations: Investigation, treatment and monitoring of late-onset hypogonadism in males
The new ISA, ISSAM, EAU, EAA and ASA recommendations on the investigation, treatment and monitoring of late-onset hypogonadism in males provide updated evidence-based information for clinicians who diagnose an...
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Article
Proteomic identification of C/EBP-DBD multiprotein complex: JNK1 activates stem cell regulator C/EBPα by inhibiting its ubiquitination
Functional inactivation of transcription factors in hematopoietic stem cell development is involved in the pathogenesis of acute myeloid leukemia (AML). Stem cell regulator C/enhancer binding protein (EBP)α is am...
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Article
Proteomic discovery of Max as a novel interacting partner of C/EBPα: a Myc/Max/Mad link
The transcription factor CCAAT/enhancer binding protein a (C/EBPα) is important in the regulation of granulopoiesis and is disrupted in human acute myeloid leukemia. In the present study, we sought to identify no...
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Article
Proteomics of acute myeloid leukaemia: cytogenetic risk groups differ specifically in their proteome, interactome and post-translational protein modifications
Acute myeloid leukaemia (AML) is characterized by specific cytogenetic aberrations that are strong determinants of prognostic outcome and therapeutic response. Because the pathological outcome of AML patients ...
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Chapter
Erkrankungen der Hoden
Der Hoden hat 2 wichtige Funktionen:eine endokrine, d.h. die Bereitstellung ausreichender Mengen des männlichen Sexualhormons Testosteron, und eine exokrine, d.h. die Bildung befruchtungsfähiger Spermien für e...
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Chapter
Erkrankungen der Hoden
Der Hoden hat 2 wichtige Funktionen:eine endokrine, d.h. die Bereitstellung ausreichender Mengen des männlichen Sexualhormons Testosteron, und eine exokrine, d.h. die Bildung befruchtungsfähiger Spermien für e...
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Chapter
Anatomie, Physiologie, Pathophysiologie
Voraussetzung für die Therapie einer Erektionsstörung ist die Kenntnis der anatomischen Strukturen und physiologischen Abläufe, die für das Entstehen, Aufrechterhalten und den Rückgang der Erektion von Bedeutu...
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Therapie
Viele Patienten, die sich wegen einer erektilen Dysfunktion erstmals in einerärztlichen Sprechstunde vorstellen, erwarten, daß Ihnen ohne größeren diagnostischen Aufwand eine einfach durchzuführende, nebenwirk...
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Chapter
Diseases of the Hypothalamus and the Pituitary Gland
Idiopathic hypogonadotropic hypogonadism (IHH) and Kallmann syndrome (Kallmann et al. 1944) are closely related diseases sharing disturbed hypothalamic secretion of GnRH as their core pathophysiological featur...
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Chapter
Diseases of the Seminal Ducts
Infections of the seminal ducts can lead to male infertility by different mechanisms. Direct damage is caused by microorganisms or their secretory products, while secondary inflammation is produced by increase...
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Chapter
Disorders of Androgen Target Organs
In this chapter, as throughout this volume, we classify diseases according to where they originate, i. e. in which organ or physiological system. All disease entities dealt with under Sect. 11.1–11.2 have in c...
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Testosterone Therapy
All forms of hypogonadism described in the previous chapters associated with Leydig cell insufficiency require testosterone therapy. In secondary hypogonadism long-term testosterone therapy is also indicated. ...
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Chapter
Assisted Fertilization
Even the most intensive diagnostic protocol cannot identify all factors contributing to infertility. Only in a few instances can treatment which eliminates all factors causing infertility be carried out. Such ...
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Chapter
Diagnosis of Male Infertility and Hypogonadism
In this chapter the diagnostic methods of andrology are presented with particular emphasis on the two main topics, male infertility and male hypogonadism. Regarding special diagnostic procedures, reference is mad...
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Disorders at the Testicular Level
Unilateral or bilateral absence of testicular tissue in genetic males is called anochia. Anorchia has to be differentiated from partial or complete testicular atrophy, e.g. following torsion of orchitis, when,...
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Chapter
Gynecology Relevant to Andrology
The care and the successful treatment of the infertile couple requires a multidisciplinary approach which supports and counsels the couple as an entity. The flowchart in Fig. 14.1 enables the non-gynecologist ...
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Chapter
Male Contribution to Contraception
Making contraceptive methods available to men is one of the tasks of andrology. Such methods are necessary both to maintain stable populations in industrial nations, as well as to diminish population growth in...
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Article
Testosteronsubstitution bei alternden Mann