43 Result(s)

Reference Work Entry In depth

Progression of Chronic Kidney Disease and Nephroprotection in Children

Progression of chronic kidney disease (CKD) towards kidney replacement therapy is inevitable in some CKD patients and once significant impairment of kidney function has occurred it tends to progress almost irr...

Elke Wühl, H. William Schnaper in Pediatric Nephrology (2022)

Living Reference Work Entry In depth

Progression of Chronic Kidney Disease and Nephroprotection in Children

Progression of chronic kidney disease (CKD) towards kidney replacement therapy is inevitable in some CKD patients and once significant impairment of kidney function has occurred it tends to progress almost irr...

Elke Wühl, H. William Schnaper in Pediatric Nephrology

Reference Work Entry In depth

SARA

Constance E. Runyan, H. William Schnaper in Encyclopedia of Signaling Molecules (2018)

Reference Work Entry In depth

Pathophysiology of Progressive Renal Disease in Children

Chronic kidney disease (CKD) is a condition in which an initial injury is superseded by a more gradual, chronic process of decreasing function that, in the most extreme cases, ultimately leads to the need for ...

H. William Schnaper in Pediatric Nephrology (2016)

Article

Defining new surrogate markers for CKD progression

At a recent meeting of international experts on clinical aspects of progressive chronic kidney disease (CKD), an extensive analysis of extant clinical trials was used to develop more effective and economical s...

H. William Schnaper, Susan L. Furth, Lynne P. Yao in Pediatric Nephrology (2015)

Article

Tubulointerstitial injury and the progression of chronic kidney disease

In chronic kidney disease (CKD), once injury from any number of disease processes reaches a threshold, there follows an apparently irreversible course toward decline in kidney function. The tubulointerstitium ...

Kavita S. Hodgkins, H. William Schnaper in Pediatric Nephrology (2012)

Article

A conceptual framework for the molecular pathogenesis of progressive kidney disease

The data regarding the pathogenesis of progressive kidney disease implicate cytokine effects, physiological factors, and myriad examples of relatively nonspecific cellular dysfunction. The sheer volume of info...

H. William Schnaper, Susan C. Hubchak, Constance E. Runyan… in Pediatric Nephrology (2010)

Reference Work Entry In depth

Pediatric Nephrology Around the World – North America

Pediatric nephrologists in North America care for children who have a wide variety of acute and chronic kidney diseases. Two registries provide insight into the current state of chronic kidney disease in pedia...

Lisa M. Satlin, Sharon P. Andreoli, H. William Schnaper in Pediatric Nephrology (2009)

Protocol

Renal Fibrosis

The kidney has unique attributes that are related to its complex structure and that affect the nature of fibrogenesis in this organ. It is divided into functional units, called nephrons, that have both a filte...

H. William Schnaper in Fibrosis Research (2005)

Chapter

Hormonal Regulation of Gonadal Angiogenesis

In the reproductive system, the rapid growth and regression of decidual tissue depends on concomitant increases and decreases in the extent of the vascular network supporting that tissue. This suggests that, l...

H. William Schnaper, Constance E. Runyan in Vascular Morphogenesis in the Female Repro… (2001)

Article

Estradiol enhances endothelial cell interactions with extracellular matrix proteins via an increase in integrin expression and function

Premenopausal women have a lower cardiovascular risk and a higher incidence of several autoimmune diseases involving blood vessels than men. Although the precise effects of estrogens on the cardiovascular syst...

Maria C. Cid, Jordi Esparza, H. William Schnaper, Manel Juan, Jordi Yague… in Angiogenesis (1999)

Article

Cell signal transduction through the mitogen-activated protein kinase pathway

H. William Schnaper in Pediatric Nephrology (1998)

Article

Integrin receptors, the cytoskeleton, and glomerular cell function

H. William Schnaper in Pediatric Nephrology (1996)

Article

Balance between matrix synthesis and degradation: a determinant of glomerulosclerosis

In glomerular health and disease, the balance between extracellular matrix (ECM) protein synthesis and degradation determines the amount of matrix that accumulates locally. While cell and whole animal regulati...

H. William Schnaper in Pediatric Nephrology (1995)