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  1. No Access

    Article

    C-terminal BRE overexpression in 11q23-rearranged and t(8;16) acute myeloid leukemia is caused by intragenic transcription initiation

    Overexpression of the BRE (brain and reproductive organ-expressed) gene defines a distinct pediatric and adult acute myeloid leukemia (AML) subgroup. Here we identify a promoter enriched for active chromatin mark...

    A E Marneth, K H M Prange, A S A Al Hinai, S M Bergevoet, N Tesi… in Leukemia (2018)

  2. Article

    Erratum: miR-194-5p/BCLAF1 deregulation in AML tumorigenesis

    Correction to: Leukemia (2017) 31, 2315–2325; doi:10.1038/leu.2017.64; published online 10 March 2017 Following the publication of this article, the authors noted a mistake in the author affiliations. 4. Centr...

    C Dell'Aversana, C Giorgio, L D'Amato, G Lania, F Matarese, S Saeed… in Leukemia (2018)

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  3. Article

    Open Access

    miR-194-5p/BCLAF1 deregulation in AML tumorigenesis

    Deregulation of epigenetic mechanisms, including microRNA, contributes to leukemogenesis and drug resistance by interfering with cancer-specific molecular pathways. Here, we show that the balance between miR-1...

    C Dell'Aversana, C Giorgio, L D'Amato, G Lania, F Matarese, S Saeed… in Leukemia (2017)

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  4. Article

    Open Access

    MLL-AF9 and MLL-AF4 oncofusion proteins bind a distinct enhancer repertoire and target the RUNX1 program in 11q23 acute myeloid leukemia

    In 11q23 leukemias, the N-terminal part of the mixed lineage leukemia (MLL) gene is fused to >60 different partner genes. In order to define a core set of MLL rearranged targets, we investigated the genome-wid...

    K H M Prange, A Mandoli, T Kuznetsova, S-Y Wang, A M Sotoca, A E Marneth… in Oncogene (2017)

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  5. Article

    Open Access

    The oncofusion protein FUS–ERG targets key hematopoietic regulators and modulates the all-trans retinoic acid signaling pathway in t(16;21) acute myeloid leukemia

    The ETS transcription factor ERG has been implicated as a major regulator of both normal and aberrant hematopoiesis. In acute myeloid leukemias harboring t(16;21), ERG function is deregulated due to a fusion w...

    A M Sotoca, K H M Prange, B Reijnders, A Mandoli, L N Nguyen, H G Stunnenberg… in Oncogene (2016)

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  6. Article

    Open Access

    CBFB–MYH11/RUNX1 together with a compendium of hematopoietic regulators, chromatin modifiers and basal transcription factors occupies self-renewal genes in inv(16) acute myeloid leukemia

    Different mechanisms for CBFβ–MYH11 function in acute myeloid leukemia with inv(16) have been proposed such as tethering of RUNX1 outside the nucleus, interference with transcription factor complex assembly an...

    A Mandoli, A A Singh, P W T C Jansen, A T J Wierenga, H Riahi, G Franci… in Leukemia (2014)

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  7. Article

    Open Access

    Genome-wide functions of PML–RARα in acute promyelocytic leukaemia

    PML—RAR (retinoic acid receptor)α is the hallmark protein of acute promyelocytic leukaemia, a highly malignant subtype of acute myeloid leukaemia that accounts for approximately 10% of all AML cases. Recently, se...

    S Saeed, C Logie, H G Stunnenberg, J H A Martens in British Journal of Cancer (2011)

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