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Article
Open AccessPoMeLo: a systematic computational approach to predicting metabolic loss in pathogen genomes
Genome streamlining, the process by which genomes become smaller and encode fewer genes over time, is a common phenomenon among pathogenic bacteria. This reduction is driven by selection for minimized energy e...
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Article
Open AccessGlobal disparities in SARS-CoV-2 genomic surveillance
Genomic sequencing is essential to track the evolution and spread of SARS-CoV-2, optimize molecular tests, treatments, vaccines, and guide public health responses. To investigate the global SARS-CoV-2 genomic ...
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Article
Open AccessPredicting the evolution of the Lassa virus endemic area and population at risk over the next decades
Lassa fever is a severe viral hemorrhagic fever caused by a zoonotic virus that repeatedly spills over to humans from its rodent reservoirs. It is currently not known how climate and land use changes could aff...
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Article
Open AccessAntibody escape and global spread of SARS-CoV-2 lineage A.27
In spring 2021, an increasing number of infections was observed caused by the hitherto rarely described SARS-CoV-2 variant A.27 in south-west Germany. From December 2020 to June 2021 this lineage has been dete...
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Open AccessEmergence and spread of SARS-CoV-2 lineage B.1.620 with variant of concern-like mutations and deletions
Distinct SARS-CoV-2 lineages, discovered through various genomic surveillance initiatives, have emerged during the pandemic following unprecedented reductions in worldwide human mobility. We here describe a SA...
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Open AccessConserved ancestral tropical niche but different continental histories explain the latitudinal diversity gradient in brush-footed butterflies
The global increase in species richness toward the tropics across continents and taxonomic groups, referred to as the latitudinal diversity gradient, stimulated the formulation of many hypotheses to explain th...
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Article
Open AccessThe ability of single genes vs full genomes to resolve time and space in outbreak analysis
Inexpensive pathogen genome sequencing has had a transformative effect on the field of phylodynamics, where ever increasing volumes of data have promised real-time insight into outbreaks of infectious disease....
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Open AccessPhylodynamic assessment of intervention strategies for the West African Ebola virus outbreak
Genetic analyses have provided important insights into Ebola virus spread during the recent West African outbreak, but their implications for specific intervention scenarios remain unclear. Here, we address th...
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Genomic epidemiology reveals multiple introductions of Zika virus into the United States
Genome sequencing of Zika virus samples from infected patients and Aedes aegypti mosquitoes in Florida shows that the virus was probably introduced into the United States on multiple occasions, and that the Carib...
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Virus genomes reveal factors that spread and sustained the Ebola epidemic
The 2013–2016 West African epidemic caused by the Ebola virus was of unprecedented magnitude, duration and impact. Here we reconstruct the dispersal, proliferation and decline of Ebola virus throughout the reg...
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The evolution of Ebola virus: Insights from the 2013–2016 epidemic
The 2013–2016 epidemic of Ebola virus disease in West Africa was of unprecedented magnitude and changed our perspective on this lethal but sporadically emerging virus. This outbreak also marked the beginning o...
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Real-time, portable genome sequencing for Ebola surveillance
A nanopore DNA sequencer is used for real-time genomic surveillance of the Ebola virus epidemic in the field in Guinea; the authors demonstrate that it is possible to pack a genomic surveillance laboratory in ...
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Open AccessTemporal and spatial analysis of the 2014–2015 Ebola virus outbreak in West Africa
Analysis of 179 new Ebola virus sequences from patient samples collected in Guinea between March 2014 and January 2015 shows how different lineages evolved and spread in West Africa.
