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Article
Open AccessAberrant expression of GSTM5 in lung adenocarcinoma is associated with DNA hypermethylation and poor prognosis
Glutathione-S transferases (GSTs) comprise a series of critical enzymes involved in detoxification of endogenous or xenobiotic compounds. Among several GSTs, Glutathione S-transferases mu (GSTM) has been impli...
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Article
Graphene oxide influences bacterial community and soil environments of Cd-polluted Haplic Cambisols in Northeast China
Graphene oxide (GO), a carbon nanomaterial that is widely used in the environment and other industries, may pose potential risks to ecosystems, especially the soil ecosystem. Some soils in Northeast China are ...
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Article
Cadmium Pollution Impact on the Bacterial Community of Haplic Cambisols in Northeast China and Inference of Resistant Genera
Modern industry and agriculture has aggravated heavy metal pollution of soils, of which cadmium (Cd) is among the common most toxic and widely distributed pollutants. Bacteria are a major group of microorganis...
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Article
Apoptotic cell administration enhances pancreatic islet engraftment by induction of regulatory T cells and tolerogenic dendritic cells
Apoptotic cell transfer has been found to be able to facilitate engraftment of allograft. However, the underlying mechanisms remain to be fully understood. Here we demonstrate that intravenous administration o...
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Article
Cloning and functional characterization of GMPR2, a novel human guanosine monophosphate reductase, which promotes the monocytic differentiation of HL-60 leukemia cells
To identify the biological function of a novel molecule which shows high homology with human guanosine monophosphate reductase (GMPR) and is named GMPR2.
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Article
DC-CLM, a cadherin-like molecule cloned from human dendritic cells, inhibits growth of breast cancer cells
To identify the characteristics and function of a cadherin-like molecule, cloned from a human dendritic cell (DC) cDNA library and designated DC-derived cadherin-like molecule (DC-CLM).
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Article
Cloning and characterization of a novel deletion mutant of heterogeneous nuclear ribonucleoprotein M4 from human dendritic cells
To identify differentially expressed genes from antigen-stimulated human dendritic cells (DC), subtractive cloning was adopted and more than ten novel genes differentially expressed were cloned. One is a delet...
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Article
Chemoattractive effect on the effector cells of the supernatants from melanoma cells transfected with the interleukin-2 (IL-2), IL-4 or IL-6 gene
By using the Boyden chamber system, the chemoattractive activity of the supernatants from the B16 melanoma cells transfected with the interleukin-2 (IL-2), IL-4 or IL-6 gene was investigated. We found that su...
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Article
The role of VCAM-l/VLA-4 in the activation of allogenic T cells by murine macrophages
Vascular cell adhesion molecule 1 (VCAM-1) is a member of immunoglobulin superfamily. The principal ligand for VCAM-1 is integrin α4β/VLA-4 (very late antigen 4). It was reported that VCAM-1 was expressed on m...
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Article
Involvement of MHC class I molecule and ICAM-1 in the enhancement of adhesion and cytotoxic susceptibility to immune effector cells of tumor cells transfected with the interleukin (IL)-2, IL-4 or IL-6 gene
To investigate the molecular and cellular mechanisms involved in the reduced tumorigenicity and increased immunogenicity of interleukin-2 (IL-2)-, IL-4- or IL-6-gene-transfected B16 melanoma vaccine, we have ...
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Article
In vitro andin vivo chemotactic effect of mip-lα gene transfected tumor vaccine on immune effector cells
Vaccination with chemokine gene-transfected tumor cells may be a new apporach to cancer treatment. Macrohage inflammatory protein-la (MIP-lα ) is a new type of chemokines which has chemotactic activity on effe...
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Article
Antitumor effect of granulocyte-macrophage colony-stimulating factor (GM-CSF)-gene encoded vaccinia melanoma oncolysate and its immunological mechanisms
Vaccinia melanoma oncolysate (VMO) prepared by infecting B16F10 melanoma cells with recombinant vaccinia virus encoding murine GM-CSF gene was tested for its therapeutic effect on the preestablished melanoma. ...
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Article
The effector functions of macrophages transfected with interferon-gamma gene mediated by recombinant adenovirus
Macrophages(M(φs) are not only a kind of immune effector cells but also a kind of antigen-presenting cells(APC). In order to improve their antitumor effect, we transfected interferon-gamma(IFN-γ) gene into Mφs...
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Article
Treatment of human hepatocellular carcinoma by fibroblast-mediated human interferon α gene therapy in combination with adoptive chemoimmunotherapy
The therapeutic effect of the fibroblast-mediated human interferon (IFNα) gene therapy in combination with interleukin-2 (IL-2) activated killer cells (AK)/doxorubicin (i.e., adoptive chemoimmunotherapy) on nu...
