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Article
Open AccessThe gasdermin family: emerging therapeutic targets in diseases
The gasdermin (GSDM) family has garnered significant attention for its pivotal role in immunity and disease as a key player in pyroptosis. This recently characterized class of pore-forming effector proteins is...
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Article
Open AccessMitochondrial IRG1 traps MCL-1 to induce hepatocyte apoptosis and promote carcinogenesis
Hepatocarcinogenesis is initiated by repeated hepatocyte death and liver damage, and the underlying mechanisms mediating cell death and the subsequent carcinogenesis remain to be fully investigated. Immunoresp...
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Article
Open AccessUFL1 promotes antiviral immune response by maintaining STING stability independent of UFMylation
The precise regulation of STING homeostasis is essential for its antiviral function. Post-translational modification, especially ubiquitination, is important for the regulation of STING homeostasis. Previous s...
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Article
Open AccessInnate immune imprints in SARS-CoV-2 Omicron variant infection convalescents
SARS-CoV-2 Omicron variant infection generally gives rise to asymptomatic to moderate COVID-19 in vaccinated people. The immune cells can be reprogrammed or “imprinted” by vaccination and infections to generat...
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Article
Open AccessJMJD4-demethylated RIG-I prevents hepatic steatosis and carcinogenesis
Hepatocarcinogenesis is driven by necroinflammation or metabolic disorders, and the underlying mechanisms remain largely elusive. We previously found that retinoic acid-inducible gene-I (RIG-I), a sensor for r...
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Article
Open AccessmicroRNA-199a-3p inhibits hepatic apoptosis and hepatocarcinogenesis by targeting PDCD4
Hepatic apoptosis and the initiated liver inflammation play the initial roles in inflammation-induced hepatocarcinogenesis. Molecular mechanisms underlying the regulation of hepatocyte apoptosis and their role...
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Article
Open AccessCD24 aggravates acute liver injury in autoimmune hepatitis by promoting IFN-γ production by CD4+ T cells
The T-cell-mediated immune response is implicated in many clinical hepatic injuries, such as autoimmune hepatitis and acute virus hepatitis. CD24 is widely expressed by different immune cells and plays an impo...
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Article
Open AccessMicheliolide inhibits LPS-induced inflammatory response and protects mice from LPS challenge
Sepsis is the principal cause of fatality in the intensive care units worldwide. It involves uncontrolled inflammatory response resulting in multi-organ failure and even death. Micheliolide (MCL), a sesquiterp...
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Article
Stk38 protein kinase preferentially inhibits TLR9-activated inflammatory responses by promoting MEKK2 ubiquitination in macrophages
NDR/LATS kinase family is highly conserved from yeast to human. It remains unknown whether the members of this family function in innate immune responses. Here we demonstrate that Stk38 negatively regulates TL...
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Article
Rhbdd3 controls autoimmunity by suppressing the production of IL-6 by dendritic cells via K27-linked ubiquitination of the regulator NEMO
NF-κB activity is regulated by multiple ubiquitin-dependent regulatory steps. Cao and colleagues show that the rhomboid protein Rhbdd3 recognizes K27-linked ubiquitin and prevents IL-6-mediated autoimmunity by...
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Article
Ephedrine hydrochloride inhibits PGN-induced inflammatory responses by promoting IL-10 production and decreasing proinflammatory cytokine secretion via the PI3K/Akt/GSK3β pathway
Approaches for controlling inflammatory responses and reducing the mortality rate of septic patients remain clinically ineffective; new drugs need to be identified that can induce anti-inflammatory responses. ...
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Article
Correction: Corrigendum: Phosphatase SHP-1 promotes TLR- and RIG-I-activated production of type I interferon by inhibiting the kinase IRAK1
Nat. Immunol. 9, 542–550 (2008); published online 6 April 2008; corrected after print 22 December 2010 In the version of this article initially published, the actin loading control in Figure 6b (left) was inco...
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Article
Cloning and Characterization of DULP, a Novel Ubiquitin-Like Molecule from Human Dendritic Cells
We identified a novel ubiquitin-like molecule DULP from human dendritic cells. DULP contains a domain that shares 26% identity and 34% similarity with ubiquitin, and it possesses the corresponding Ile-44 hydro...
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Article
Phosphatase SHP-1 promotes TLR- and RIG-I-activated production of type I interferon by inhibiting the kinase IRAK1
Unbalanced production of proinflammatory cytokines and type I interferons in immune responses may lead to immunopathology; thus, the mechanisms that ensure the beneficial production of proinflammatory cytokine...
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Article
EAPF/Phafin-2, a novel endoplasmic reticulum-associated protein, facilitates TNF-α-triggered cellular apoptosis through endoplasmic reticulum-mitochondrial apoptotic pathway
We recently identified the Phafin protein family, whose members all contain an N-terminal PH domain (pleckstrin homology) and a C-terminal FYVE (Fab1, YGLO23, Vps27, and EEA1) domain. LAPF (lysosome-associated...
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Article
Enhanced induction of dendritic cell maturation and HLA-A*0201-restricted CEA-specific CD8+ CTL response by exosomes derived from IL-18 gene-modified CEA-positive tumor cells
Dendritic cells (DC)-derived or tumor-derived exosomes are a population of nanometer sized membrane vesicles that can induce specific anti-tumor immunity. However, the immunogenic potential and efficiency of e...
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Article
Enhanced antitumor effect of EGF R–targeted p21WAF-1 and GM-CSF gene transfer in the established murine hepatoma by peritumoral injection
One of the major obstacles in current cancer gene therapy is the lack of a gene delivery system with high efficiency and targetability. In this paper, a nonviral gene delivery system GE7, which was designed to...
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Article
Efficient activation of antitumor immunity by IL-6 gene-modified leukemia vaccine in combination with low dose cyclophosphamide and low dose IL-2
Objective: To investigate the antitumor effect of the IL-6 gene-modified erythroleukemia cells combined with low dose cyclophosphamide (Cy) and low dose IL-2. Methods: Mice inoculated with FBL-3-IL-6 in combin...
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Article
Effects of fibroblast-mediated interleukin 3 and interleukin 6 gene therapy on hematopoiesis in mice treated with 5-fluorouracil
Fibroblast-mediated cytokine gene therapy has proven to be a promising strategy for restoring hematopoiesis following repeated chemotherapy. Interleukin 3 (IL-3) and interleukin 6 (IL-6) can synergistically pr...
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Article
Enhanced antitumor effects of suicide gene therapy by simultaneous transfer of GM-CSF gene in leukemia-bearing mice
In the present report, antitumor effect of combined transfer of suicide gene and cytokine gene was studied. Adenovirus engineered to express E. Coli. cytosine deaminase (AdCD) and/or adenovirus engineered to e...
