74 Result(s)

Article

Tagging large CNV blocks in wheat boosts digitalization of germplasm resources by ultra-low-coverage sequencing

The massive structural variations and frequent introgression highly contribute to the genetic diversity of wheat, while the huge and complex genome of polyploid wheat hinders efficient genoty** of abundant v...

Jianxia Niu, Wenxi Wang, Zihao Wang, Zhe Chen, **aoyu Zhang, Zhen Qin… in Genome Biology (2024)

Article

Genome-wide identification and expression analysis of the KNOX family and its diverse roles in response to growth and abiotic tolerance in sweet potato and its two diploid relatives

KNOXs, a type of homeobox genes that encode atypical homeobox proteins, play an essential role in the regulation of growth and development, hormonal response, and abiotic stress in plants. However, the KNOX gene ...

Li-Cong Jia, Zi-Tong Yang, Li-Li Shang, Shao-Zhen He, Huan Zhang, Xu Li… in BMC Genomics (2024)

Article

Genetic and phenotypic analysis of 225 Chinese children with developmental delay and/or intellectual disability using whole-exome sequencing

Developmental delay (DD), or intellectual disability (ID) is a very large group of early onset disorders that affects 1–2% of children worldwide, which have diverse genetic causes that should be identified. Ge...

Heqian Ma, Lina Zhu, **ao Yang, Meng Ao, Shunxiang Zhang, Meizhen Guo… in BMC Genomics (2024)

Article

Chromosome-level genome provides insight into the evolution and conservation of the threatened goral (Naemorhedus goral)

Gorals Naemorhedus resemble both goats and antelopes, which prompts much debate about the intragenus species delimitation and phylogenetic status of the genus Naemorhedus within the subfamily Caprinae. Their evol...

Nan Sun, **ao-Ying Ma, Guang-Hong Shi, **ao-Hong Yang, Wei Li… in BMC Genomics (2024)

Article

Author Correction: Genome sequencing of 2000 canids by the Dog10K consortium advances the understanding of demography, genome function and architecture

Jennifer R. S. Meadows, Jefrey M. Kidd, Guo-Dong Wang, Heidi G. Parker… in Genome Biology (2023)

Article

Transcriptome analysis reveals a lncRNA-miRNA-mRNA regulatory network in OsRpp30-mediated disease resistance in rice

Long non-coding RNAs (lncRNAs) play critical roles in various biological processes in plants. Extensive studies utilizing high-throughput RNA sequencing have revealed that many lncRNAs are involved in plant di...

Minghua Li, Wei Li, Meixia Zhao, Zhiqiang Li, Guo-Liang Wang, Wende Liu… in BMC Genomics (2023)

Article

A loss-of-function mutation in human Oxidation Resistance 1 disrupts the spatial–temporal regulation of histone arginine methylation in neurodevelopment

Oxidation Resistance 1 (OXR1) gene is a highly conserved gene of the TLDc domain-containing family. OXR1 is involved in fundamental biological and cellular processes, including DNA damage response, antioxidant pa...

**aolin Lin, Wei Wang, Mingyi Yang, Nadirah Damseh… in Genome Biology (2023)

Article

Genome sequencing of 2000 canids by the Dog10K consortium advances the understanding of demography, genome function and architecture

The international Dog10K project aims to sequence and analyze several thousand canine genomes. Incorporating 20 × data from 1987 individuals, including 1611 dogs (321 breeds), 309 village dogs, 63 wolves, and ...

Jennifer R. S. Meadows, Jeffrey M. Kidd, Guo-Dong Wang, Heidi G. Parker… in Genome Biology (2023)

Article

Genome-wide association study of quality traits and starch pasting properties of maize kernels

Starch are the main nutritional components of maize (Zea mays L.), and starch pasting properties are widely used as essential indicators for quality estimation. Based on the previous studies, various genes relate...

**nmei Guo, Zhaopeng Ge, Ming Wang, Meiai Zhao, Yuhe Pei, **yun Song in BMC Genomics (2023)

Article

Target residence of Cas9-sgRNA influences DNA double-strand break repair pathway choices in CRISPR/Cas9 genome editing

Due to post-cleavage residence of the Cas9-sgRNA complex at its target, Cas9-induced DNA double-strand breaks (DSBs) have to be exposed to engage DSB repair pathways. Target interaction of Cas9-sgRNA determine...

Si-Cheng Liu, Yi-Li Feng, **u-Na Sun, Ruo-Dan Chen, Qian Liu… in Genome Biology (2022)

Article

An ORFeome of rice E3 ubiquitin ligases for global analysis of the ubiquitination interactome

Ubiquitination is essential for many cellular processes in eukaryotes, including 26S proteasome-dependent protein degradation, cell cycle progression, transcriptional regulation, and signal transduction. Altho...

Ruyi Wang, **aoman You, Chongyang Zhang, Hong Fang, Min Wang, Fan Zhang… in Genome Biology (2022)

Article

Natural selenium stress influences the changes of antibiotic resistome in seleniferous forest soils

Metal(loid)s can promote the spread and enrichment of antibiotic resistance genes (ARGs) in the environment through a co-selection effect. However, it remains unclear whether exposure of microorganisms to vary...

Fang-Fang Wang, Guo-** Liu, Fan Zhang, Zong-Ming Li… in Environmental Microbiome (2022)

Article

Chromosome-level genome assembly of grass carp (Ctenopharyngodon idella) provides insights into its genome evolution

The grass carp has great economic value and occupies an important evolutionary position. Genomic information regarding this species could help better understand its rapid growth rate as well as its unique body...

Chang-Song Wu, Zi-You Ma, Guo-Dong Zheng, Shu-Ming Zou, Xu-Jie Zhang… in BMC Genomics (2022)

Article

Correction to: Carriage of distinct bla_KPC-2 and bla_OXA-48 plasmids in a single ST11 hypervirulent Klebsiella pneumoniae isolate in Egypt

Yanxian Yang, Yongqiang Yang, Mohamed Abd El-Gawad El-Sayed Ahmed… in BMC Genomics (2022)

Article

Comparative genomic analyses of Polymyxin-resistant Enterobacteriaceae strains from China

Mobile colistin resistance like gene (mcr-like gene) is a new type of polymyxin resistance gene that can be horizontally transferred in the Enterobacteriaceae. This has brought great challenges to the treatment o...

Zhien He, Yongqiang Yang, Wei Li, **aoling Ma, Changfeng Zhang… in BMC Genomics (2022)

Article

Knockout of circRNAs by base editing back-splice sites of circularized exons

Many circular RNAs (circRNAs) are produced from back-splicing of exons of precursor mRNAs and are generally co-expressed with cognate linear RNAs. Methods for circRNA-specific knockout are lacking, largely due...

**ang Gao, Xu-Kai Ma, **ang Li, Guo-Wei Li, Chu-**ao Liu, Jun Zhang… in Genome Biology (2022)

Article

Carriage of distinct bla_KPC-2 and bla_OXA-48 plasmids in a single ST11 hypervirulent Klebsiella pneumoniae isolate in Egypt

Carbapenem-resistant hypervirulent K. pneumoniae (CR-hvKP) causes serious infections with significant morbidity and mortality. However, the epidemiology and transmission mechanisms of CR-hvKP and the correspondin...

Yanxian Yang, Yongqiang Yang, Mohamed Abd El-Gawad El-Sayed Ahmed… in BMC Genomics (2022)

Article

Microbial co-occurrence complicates associations of gut microbiome with US immigration, dietary intake and obesity

Obesity and related comorbidities are major health concerns among many US immigrant populations. Emerging evidence suggests a potential involvement of the gut microbiome. Here, we evaluated gut microbiome feat...

Zheng Wang, Mykhaylo Usyk, Yoshiki Vázquez-Baeza, Guo-Chong Chen… in Genome Biology (2021)

Article

Map** the evolving landscape of super-enhancers during cell differentiation

Super-enhancers are clusters of enhancer elements that play critical roles in the maintenance of cell identity. Current investigations on super-enhancers are centered on the established ones in static cell typ...

Yan Kai, Bin E. Li, Ming Zhu, Grace Y. Li, Fei Chen, Yingli Han… in Genome Biology (2021)

Article

Effective control of large deletions after double-strand breaks by homology-directed repair and dsODN insertion

After repairing double-strand breaks (DSBs) caused by CRISPR-Cas9 cleavage, genomic damage, such as large deletions, may have pathogenic consequences.

Wei Wen, Zi-Jun Quan, Si-Ang Li, Zhi-Xue Yang, Ya-Wen Fu, Feng Zhang… in Genome Biology (2021)