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Open AccessPerfusion deficits may underlie lung and kidney injury in severe COVID-19 disease: insights from a multicenter international cohort study
Lung perfusion defects, mainly due to endothelial and coagulation activation, are a key contributor to COVID-19 respiratory failure. COVID-19 patients may also develop acute kidney injury (AKI) because of rena...
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Article
Open AccessPulmonary shunt in critical care: a practical approach with clinical scenarios
Pulmonary shunt refers to the passage of venous blood into the arterial blood system bypassing the alveoli-blood gas exchange. Pulmonary shunt is defined by a drop in the physiologic coupling of lung ventilati...
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Role of PEEP on the prognostic performance of the ROX index in hypoxemic respiratory failure due to COVID-19: any further gain in outcome prediction?
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Open AccessTime course of risk factors associated with mortality of 1260 critically ill patients with COVID-19 admitted to 24 Italian intensive care units
To evaluate the daily values and trends over time of relevant clinical, ventilatory and laboratory parameters during the intensive care unit (ICU) stay and their association with outcome in critically ill pati...
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Plateau and driving pressure in the presence of spontaneous breathing
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Respiratory pattern during neurally adjusted ventilatory assist in acute respiratory failure patients
To investigate the effect of a wide range of assistance levels during neurally adjusted ventilatory assist (NAVA) and pressure support ventilation (PSV) on respiratory pattern, breathing variability, and incid...
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Successful use of neurally adjusted ventilatory assist in a patient with extremely low respiratory system compliance undergoing ECMO
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Continuous flow biphasic positive airway pressure by helmet in patients with acute hypoxic respiratory failure: effect on oxygenation
We investigated the effects of periodical high pressure breaths (SIGH) or biphasic positive pressure ventilation (BIPAP) during helmet continuous positive airway pressure (CPAP) in patients with acute hypoxic ...
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Article
Short-term evaluation of sedation with sevoflurane administered by the anesthetic conserving device in critically ill patients
Assessing feasibility and physiological effects of sedation with sevoflurane, administered with the anesthetic conserving device (AnaConDa), in comparison with propofol and remifentanil.
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An improved Boussignac device for the delivery of non-invasive CPAP: the SUPER-Boussignac
The purpose of this study is to describe and test a modified Boussignac system for non-invasive continuous positive airway pressure, aimed at reducing the decrease in inspiratory oxygen fraction (FiO2) with highe...
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Is helmet CPAP first line pre-hospital treatment of presumed severe acute pulmonary edema?
Non-invasive continuous positive airway pressure (CPAP) is effective in reducing intubation rate and mortality of patient with acute cardiogenic pulmonary edema (ACPE). We report our experience on pre-hospital...
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Lung volume in mechanically ventilated patients: measurement by simplified helium dilution compared to quantitative CT scan
We describe a simplified helium dilution technique to measure end-expiratory lung volume (EELV) in mechanically ventilated patients. We assessed both its accuracy in comparison with quantitative computerized ...
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Head helmet versus face mask for non-invasive continuous positive airway pressure: a physiological study
To assess selected physiological effects of non-invasive continuous positive airway pressure delivered by head helmet (CPAPH), a special interface device designed to completely contain the head of the patient, co...
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Translaryngeal tracheostomy in acute respiratory distress syndrome patients
Objective: To prevent gas exchange deterioration during translaryngeal tracheostomy (TLT) in patients with acute respiratory distress syndrome (ARDS) ventilation is maintained through a small dia...