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Article
Open AccessTwelve-hour normothermic liver perfusion in a rat model: characterization of the changes in the ex-situ bio-molecular phenotype and metabolism
The partial understanding of the biological events that occur during normothermic machine perfusion (NMP) and particularly during prolonged perfusion might hinder its deployment in clinical transplantation. Th...
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Article
Open AccessCurrent knowledge gaps in extracorporeal respiratory support
Extracorporeal life support (ECLS) for acute respiratory failure encompasses veno-venous extracorporeal membrane oxygenation (V-V ECMO) and extracorporeal carbon dioxide removal (ECCO2R). V-V ECMO is primarily us...
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Article
Open AccessLongitudinal assessment of renal function after lung transplantation for cystic fibrosis: transition from post-operative acute kidney injury to acute kidney disease and chronic kidney failure
The clinical trajectory of post-operative acute kidney injury (AKI) following lung transplantation for cystic fibrosis is unknown.
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Article
Open AccessCerebrospinal Fluid and Arterial Acid–Base Equilibrium of Spontaneously Breathing Patients with Aneurismal Subarachnoid Hemorrhage
Hyperventilation resulting in hypocapnic alkalosis (HA) is frequently encountered in spontaneously breathing patients with acute cerebrovascular conditions. The underlying mechanisms of this respiratory respon...
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Article
Open AccessCOVID-19 ICU mortality prediction: a machine learning approach using SuperLearner algorithm
Since the beginning of coronavirus disease 2019 (COVID-19), the development of predictive models has sparked relevant interest due to the initial lack of knowledge about diagnosis, treatment, and prognosis. Th...
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Article
Open AccessTime course of risk factors associated with mortality of 1260 critically ill patients with COVID-19 admitted to 24 Italian intensive care units
To evaluate the daily values and trends over time of relevant clinical, ventilatory and laboratory parameters during the intensive care unit (ICU) stay and their association with outcome in critically ill pati...
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Article
Open AccessMechanical ventilation parameters in critically ill COVID-19 patients: a sco** review
The mortality of critically ill patients with COVID-19 is high, particularly among those receiving mechanical ventilation (MV). Despite the high number of patients treated worldwide, data on respiratory mechan...
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Article
Open AccessUse of critical care resources during the first 2 weeks (February 24–March 8, 2020) of the Covid-19 outbreak in Italy
A Covid-19 outbreak developed in Lombardy, Veneto and Emilia-Romagna (Italy) at the end of February 2020. Fear of an imminent saturation of available ICU beds generated the notion that rationing of intensive c...
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Article
Open AccessParoxysmal Nocturnal Hemoglobinuria (Pnh): Brain Mri Ischemic Lesions In Neurologically Asymtomatic Patients
This study investigated for the first time brain ischemic involvement in 19 consecutive neurologically asymptomatic PNH patients by non-enhanced cerebral MRI, and by intracranial arterial and venous angio-MRI....
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Article
Randomized, multicenter trial of lateral Trendelenburg versus semirecumbent body position for the prevention of ventilator-associated pneumonia
The lateral Trendelenburg position (LTP) may hinder the primary pathophysiologic mechanism of ventilator-associated pneumonia (VAP). We investigated whether placing patients in the LTP would reduce the inciden...
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Article
ECMO for intractable status asthmaticus following atracurium
Intraoperative allergic reactions are rare but serious events associated with increased morbidity and mortality. We report the salvage of intraoperative anaphylaxis leading to extreme hypercapnic respiratory f...
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Article
Open Access‘Gardos Channelopathy’: a variant of hereditary Stomatocytosis with complex molecular regulation
The Gardos channel is a Ca2+ sensitive, K+ selective channel present in several tissues including RBCs, where it is involved in cell volume regulation. Recently, mutations at two different aminoacid residues in K...
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Article
Will all ARDS patients be receiving mechanical ventilation in 2035? No
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Chapter and Conference Paper
Connected Vehicles for Safety Enhancement: Reliability of Beaconing in Urban Areas
Safety enhancement is the main objective to pursue through the exploitation of connected vehicles. To this aim, the exchange of periodic beacon messages through vehicle-to-vehicle (V2V) communications is essen...
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Article
Performance evaluation of softer vertical handovers in multiuser heterogeneous wireless networks
In the future fifth generation (5G) networked society, devices will integrate heterogeneous radio access technologies (RATs) to improve the network performance and the user quality of experience. In this pape...
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Article
Daily nursing care on patients undergoing venous–venous extracorporeal membrane oxygenation: a challenging procedure!
Daily nursing in critical care patients may alter vital parameters, especially in the most critically ill patients. The aim of our study was to evaluate feasibility and safety of daily nursing on patients unde...
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Article
Extremely high transpulmonary pressure in a spontaneously breathing patient with early severe ARDS on ECMO
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Article
Personalized medicine for ARDS: the 2035 research agenda
In the last 20 years, survival among patients with acute respiratory distress syndrome (ARDS) has increased substantially with advances in lung-protective ventilation and resuscitation. Building on this succes...
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Article
Understanding the role of the cerebrospinal fluid in acid–base disorders
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Article
Effects on membrane lung gas exchange of an intermittent high gas flow recruitment maneuver: preliminary data in veno-venous ECMO patients
Gas exchange capabilities of polymethylpentene membrane lungs (MLs) worsen over time. ML deterioration is related to protein deposit and clot formation. Condensation and trap** of water vapor inside ML hollo...
