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Open AccessEnvironmental fatty acids enable emergence of infectious Staphylococcus aureus resistant to FASII-targeted antimicrobials
The bacterial pathway for fatty acid biosynthesis, FASII, is a target for development of new anti-staphylococcal drugs. This strategy is based on previous reports indicating that self-synthesized fatty acids a...
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Chapter
Responses of Lactic Acid Bacteria to Oxidative Stress
Lactic acid bacteria (LAB) include those designated as generally recognized as safe (LABGRAS), used in dairy industries, and opportunistic pathogens like most of the streptococceae. They are usually classified as...
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Brinster et al. reply
Replying to: W. Balemans et al. Nature 462, 10.1038/nature08667 (2009)
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Type II fatty acid synthesis is not a suitable antibiotic target for Gram-positive pathogens
The type II fatty acid synthesis (FASII) pathway has been suggested to be a promising antimicrobial target, and the antibiotics platensimycin and platencin that target this pathway are claimed to be potentiall...
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Getting high (OD) on heme
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Roles of Environmental Heme, and Menaquinone, in Streptococcus Agalactiae
Most bacteria require iron for growth. However, as it may not be directly available under aerobic conditions, bacteria may use iron-sequestering molecules, such as bacterially encoded siderophores, or heme, wh...
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Article
Respiration capacity and consequences in Lactococcus lactis
We recently reported that the well-studied fermenting bacterium Lactococcus lactis could grow via a respirative metabolism in the presence of oxygen when a heme source is present. Respiration induces profound cha...
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Chapter
Respiration capacity and consequences in Lactococcus lactis
We recently reported that the well-studied fermenting bacterium Lactococcus lactis could grow via a respirative metabolism in the presence of oxygen when a heme source is present. Respiration induces profound cha...
